产品描述: | IMR-1 is a novel class of Notch inhibitor targeting the transcriptional activation with an IC50 of 26 μM. IMR-1 prevents the recruitment of Mastermind-like 1 (Maml1) to the Notch Ternary Complex (NTC) on chromatin, inhibits Notch target gene transcription and dramatically inhibits tumor growth |
靶点: |
IC50: 26 nM (Notch);Gamma-secretase |
体内研究: |
IMR-1 (i.p.; 15mg/kg; for 28 days) inhibits Notch-dependent tumor growth in patient-derived xenograft models. Animal Model: Nude mouses with adenocarcinoma xenograft Dosage: 15mg/kg Administration: I.p.; for 28 days Result: Blocks tumor establishment. |
参考文献: |
1. Astudillo L et al. The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis. Cancer Res. 2016 Jun 15;76(12):3593-603. |
溶解性: |
soluble in DMSO |
保存条件: |
-20℃ |
配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
1 mM |
2.83 ml |
14.148 ml |
28.295 ml |
5 mM |
0.566 ml |
2.83 ml |
5.659 ml |
10 mM |
0.283 ml |
1.415 ml |
2.83 ml |
50 mM |
0.057 ml |
0.283 ml |
0.566 ml |
|
注意: |
部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。 |