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产品描述： Regadenoson (CVT-3146) is a selective A2A adenosine receptor agonist and vasodilator that increases coronary blood flow, can be used in study of myocardial perfusion imaging. Regadenoson also increases the permeability of the blood-brain barrier (BBB) in rodents, can be used to study increased delivery of drugs to the human CNS |
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靶点：
Adenosine Receptor;AdenosineReceptor |
体内研究：
Regadenoson (0.1, 0.175, 0.25, 0.5, 1.0, 2.5, 5 µg/kg; p.i.v.; single) increases coronary blood flow (CBF) and decreases in mean coronary resistance in a dose-dependent manner, in awake dogs. Regadenoson (2.5 µg/kg; p.i.v.; single in 30 s) increases blood flow of coronary in awake dogs. Regadenoson (0.5 µg/kg; i.v.; single; 60 or 90 min after Temozolomide administration) promotes Temozolomide delivery to CNS of rats. |
参考文献：
1. Trochu JN, et al. Selective A2A adenosine receptor agonist as a coronary vasodilator in conscious dogs: potential for use in myocardial perfusion imaging. J Cardiovasc Pharmacol. 2003 Jan;41(1):132-9. 2. Jackson S, et al. The effect of regadenoson-induced transient disruption of the blood-brain barrier on temozolomide delivery to normal rat brain. J Neurooncol. 2016 Feb;126(3):433-9. |
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溶解性：
DMSO : 50 mg/mL (128.09 mM; Need ultrasonic) |
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保存条件：
-20℃ |
配置溶液浓度参考：
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1mg |
5mg |
10mg |
| 1 mM |
2.562 ml |
12.809 ml |
25.618 ml |
| 5 mM |
0.512 ml |
2.562 ml |
5.124 ml |
| 10 mM |
0.256 ml |
1.281 ml |
2.562 ml |
| 50 mM |
0.051 ml |
0.256 ml |
0.512 ml |
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| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
北京