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• 产品描述： Regadenoson (CVT-3146) is a selective A2A adenosine receptor agonist and vasodilator that increases coronary blood flow, can be used in study of myocardial perfusion imaging. Regadenoson also increases the permeability of the blood-brain barrier (BBB) in rodents, can be used to study increased delivery of drugs to the human CNS

• 靶点： Adenosine Receptor;AdenosineReceptor

• 体内研究：
  Regadenoson (0.1, 0.175, 0.25, 0.5, 1.0, 2.5, 5 µg/kg; p.i.v.; single) increases coronary blood flow (CBF) and decreases in mean coronary resistance in a dose-dependent manner, in awake dogs. Regadenoson (2.5 µg/kg; p.i.v.; single in 30 s) increases blood flow of coronary in awake dogs. Regadenoson (0.5 µg/kg; i.v.; single; 60 or 90 min after Temozolomide administration) promotes Temozolomide delivery to CNS of rats.

• 参考文献：
  1. Trochu JN, et al. Selective A2A adenosine receptor agonist as a coronary vasodilator in conscious dogs: potential for use in myocardial perfusion imaging. J Cardiovasc Pharmacol. 2003 Jan;41(1):132-9. 2. Jackson S, et al. The effect of regadenoson-induced transient disruption of the blood-brain barrier on temozolomide delivery to normal rat brain. J Neurooncol. 2016 Feb;126(3):433-9.

• 溶解性： DMSO  :  50  mg/mL  (128.09  mM;  Need  ultrasonic)

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.562 ml	12.809 ml	25.618 ml
  5 mM	0.512 ml	2.562 ml	5.124 ml
  10 mM	0.256 ml	1.281 ml	2.562 ml
  50 mM	0.051 ml	0.256 ml	0.512 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *