| 产品描述： | T0070907 is a potent PPARγ antagonist with a Ki of 1 nM. |
| 靶点： |
PPARγ:1 nM (Ki);PPARδ:1.8 μM (Ki);PPARα:0.85 μM (Ki);PPAR |
| 参考文献： |
1. An Z, et al. T0070907 inhibits repair of radiation-induced DNA damage by targeting RAD51. Toxicol In Vitro. 2016 Dec;37:1-8 2. An Z, et al. T0070907, a PPAR γ inhibitor, induced G2/M arrest enhances the effect of radiation in human cervical cancer cells through mitotic catastrophe. Reprod Sci. 2014 Nov;21(11):1352-61. 3. Kawahara A, et al. Peroxisome proliferator-activated receptor γ (PPARγ)-independent specific cytotoxicity against immature adipocytes induced by PPARγ antagonist T0070907. Biol Pharm Bull. 2013;36(9):1428-34 4. Lee G, et al. T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities. J Biol Chem. 2002 May 31;277(22):19649-57. Epub 2002 Mar 4 |
| 溶解性： |
DMSO : 62.5 mg/mL (225.10 mM; ultrasonic and warming and heat to 60°C) H2O : 1.1 mg/mL (3.96 mM; Need ultrasonic) |
| 保存条件： |
-20℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
3.602 ml |
18.008 ml |
36.015 ml |
| 5 mM |
0.72 ml |
3.602 ml |
7.203 ml |
| 10 mM |
0.36 ml |
1.801 ml |
3.602 ml |
| 50 mM |
0.072 ml |
0.36 ml |
0.72 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京