GlyH-101 99%

N-2-Naphthalenyl-glycine 2-[(3,5-Dibromo-2,4-dihydroxyphenyl)methylene]hydrazide

源叶(MedMol)
S80641
328541-79-3
C19H15Br2N3O3
493.15
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶(MedMol) S80641-1mg 99% ¥140.00元 10 - - -
源叶(MedMol) S80641-2mg 99% ¥240.00元 10 - - -
源叶(MedMol) S80641-5mg 99% ¥330.00元 7 - - -
源叶(MedMol) S80641-10mg 99% ¥590.00元 7 - - -
源叶(MedMol) S80641-25mg 99% ¥1370.00元 4 - - -
源叶(MedMol) S80641-50mg 99% ¥2380.00元 预计交期:2-3天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

GlyH-101 is a potent CFTR inhibitor. GlyH-101 also is a potent and reversible inhibitor of the VSORC conductance. GlyH-101 shows antiproliferative activity. GlyH-101 inhibits CFTR-like current and VSORC current
产品描述: GlyH-101 is a potent CFTR inhibitor. GlyH-101 also is a potent and reversible inhibitor of the VSORC conductance. GlyH-101 shows antiproliferative activity. GlyH-101 inhibits CFTR-like current and VSORC current
靶点: CFTR;CFTR;Autophagy
体内研究: GlyH-101 (2.5 µg) reduces by about 80% cholera toxin-induced intestinal fluid secretion in mouse
参考文献: 1. Muanprasat C, et al. Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy. J Gen Physiol. 2004 Aug;124(2):125-37. 2. Kelly M, et al. Cystic fibrosis transmembrane regulator inhibitors CFTR(inh)-172 and GlyH-101 target mitochondrial functions, independently of chloride channel inhibition. J Pharmacol Exp Ther. 2010 Apr;333(1):60-9. 3. Barman PP, et al. Cardiac ion channel current modulation by the CFTR inhibitor GlyH-101. Biochem Biophys Res Commun. 2011 Apr 29;408(1):12-7. 4. Melis N, et al. Revisiting CFTR inhibition: a comparative study of CFTRinh -172 and GlyH-101 inhibitors. Br J Pharmacol. 2014 Aug;171(15):3716-27. 5. Muanprasat C, et al. Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy. J Gen Physiol. 2004 Aug;124(2):125-37.
溶解性: DMSO  :  ≥  58  mg/mL  (117.61  mM)
保存条件: 2-8℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.028 ml 10.139 ml 20.278 ml
5 mM 0.406 ml 2.028 ml 4.056 ml
10 mM 0.203 ml 1.014 ml 2.028 ml
50 mM 0.041 ml 0.203 ml 0.406 ml
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参考文献

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摩尔浓度计算器

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