| 产品描述： | Procarbazine Hydrochloride is an orally active alkylating agent, with anticancer activity. Procarbazine Hydrochloride can be used in Hodgkin's disease research |
| 靶点： |
DNA Alkylator/Crosslinker;DNAAlkylator/Crosslinker; DNA/RNASynthesis |
| 体内研究： |
Procarbazine (Intraperitoneal injection; 50 and 150 mg/kg; once daily; 5 d) induces micronuclei in hematopoietic cells, but not increases the lacZ mutant frequency (MF) in bone marrow |
| 参考文献： |
1. J M Erikson, et al. Cytotoxicity and DNA damage caused by the azoxy metabolites of procarbazine in L1210 tumor cells. Cancer Res. 1989 Jan 1;49(1):127-33. 2. T Suzuki, et al. Procarbazine genotoxicity in the MutaMouse; strong clastogenicity and organ-specific induction of lacZ mutations. Mutat Res. 1999 Aug 18;444(2):269-81. |
| 溶解性： |
H2O : 100 mg/mL (387.96 mM; Need ultrasonic) DMSO : 16.67 mg/mL (64.67 mM; Need ultrasonic) |
| 保存条件： |
2-8℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
3.88 ml |
19.398 ml |
38.796 ml |
| 5 mM |
0.776 ml |
3.88 ml |
7.759 ml |
| 10 mM |
0.388 ml |
1.94 ml |
3.88 ml |
| 50 mM |
0.078 ml |
0.388 ml |
0.776 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京