| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
S80688-1mg |
99.5% | ￥216.00 | 1 | - | - | - |
|
S80688-2mg |
99.5% | ￥352.00 | 4 | - | - | - |
|
S80688-5mg |
99.5% | ￥720.00 | 4 | - | - | - |
|
S80688-10mg |
99.5% | ￥960.00 | 6 | - | - | - |
|
S80688-25mg |
≥98% | ￥1920.00 | 货期：2-3天 | - | - | - |
|
S80688-50mg |
≥98% | ￥3600.00 | 货期：2-3天 | - | - | - |
|
S80688-100mg |
≥98% | ￥5600.00 | 货期：2-3天 | - | - | - |
|
YM-201636 is a potent and selective PIKfyve inhibitor with an IC50 of 33 nM. YM-201636 also inhibits p110α with an IC50 of 3.3 μM. YM-201636 inhibits retroviral replication.
| 产品描述： | YM-201636 is a potent and selective PIKfyve inhibitor with an IC50 of 33 nM. YM-201636 also inhibits p110α with an IC50 of 3.3 μM. YM-201636 inhibits retroviral replication. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | PIKfyve:33 nM (IC50);p110α:3.3 μM (IC50);Autophagy ;InfluenzaVirus;PI3K;Autophagy | ||||||||||||||||||||
| 参考文献： | 1. Jefferies HB, et al. A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding. EMBO Rep, 2008, 9(2), 164-170. 2. Ikonomov OC, et al. YM-201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, halts glucose entry by insulin in adipocytes. Biochem Biophys Res Commun. 2009 May 8;382(3):566-70. 3. Sbrissa D, et al. Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM-201636. Am J Physiol Cell Physiol. 2012 Aug 15;303(4):C436-46. 4. Dukes JD, et al. The PIKfyve inhibitor YM-201636 blocks the continuous recycling of the tight junction proteins claudin-1 and claudin-2 in MDCK cells. PLoS One. 2012;7(3):e28659. 5. Ikonomov OC, et al. YM201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, halts glucose entry by insulin in adipocytes. Biochem Biophys Res Commun. 2009 May 8;382(3):566-70. | ||||||||||||||||||||
| 溶解性： | DMSO : ≥ 47 mg/mL (100.54 mM) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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