Dacinostat 97%

2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)-

源叶(MedMol)
S80700
404951-53-7
C22H25N3O3
379.4522
达诺司他;达西司特;达诺斯他 DACINOSTAT, NVP-LAQ 824;LAQ824 (DACINOSTAT);2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)-;(E)-N-hydroxy-3-[4-[[2-hydroxyethyl-[2-(
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶(MedMol) S80700-5mg 97% ¥500.00元 6 - - -
源叶(MedMol) S80700-10mg 97% ¥900.00元 6 - - -
源叶(MedMol) S80700-50mg 97% ¥2700.00元 3 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

Dacinostat is a potent HDAC inhibitor, with an IC50 of 32 nM; Dacinostat also inhibits HDAC1 with an IC50 of 9 nM, and used in cancer research.
产品描述: Dacinostat is a potent HDAC inhibitor, with an IC50 of 32 nM; Dacinostat also inhibits HDAC1 with an IC50 of 9 nM, and used in cancer research.
靶点: HDAC1:9 nM (IC50);HDAC:32 nM (IC50);HDAC;Autophagy
体内研究: NVP-LAQ824 produces a dose-dependent inhibition of tumor growth, and at 100 mg/kg, its antitumor effect is similar to that of 5-Fluorouracil
参考文献: 1. Atadja P, et al. Selective growth inhibition of tumor cells by a novel histone deacetylase inhibitor, NVP-LAQ824. Cancer Res. 2004 Jan 15;64(2):689-95. 2. Cho YS, et al. Conformational refinement of hydroxamate-based histone deacetylase inhibitors and exploration of 3-piperidin-3-ylindole analogues of dacinostat (LAQ824). J Med Chem. 2010 Apr 8;53(7):2952-63. 3. Romanski A, et al. Deacetylase inhibitors modulate proliferation and self-renewal properties of leukemic stem and progenitor cells. Cell Cycle. 2012 Sep 1;11(17):3219-26.
溶解性: DMSO  :  ≥  43  mg/mL  (113.32  mM)
保存条件: 2-8℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.635 ml 13.177 ml 26.354 ml
5 mM 0.527 ml 2.635 ml 5.271 ml
10 mM 0.264 ml 1.318 ml 2.635 ml
50 mM 0.053 ml 0.264 ml 0.527 ml
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参考文献

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