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Dobutamine Hydrochloride 98%(HPLC)

Dobutamine Hydrochloride

源叶(MedMol)
S80744
49745-95-1
C18H24ClNO3
337.84
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶(MedMol) S80744-25mg 98%(HPLC) ¥260.00元 6 - - -
源叶(MedMol) S80744-100mg 98%(HPLC) ¥840.00元 6 - - -
源叶(MedMol) S80744-250mg 98%(HPLC) ¥1500.00元 3 - - -
源叶(MedMol) S80744-1g 98%(HPLC) ¥3800.00元 3 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion
产品描述: Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion
靶点: Adrenergic Receptor;AdrenergicReceptor
体内研究:
Dobutamine hydrochloride has a rapid onset of action and a short half-life . Dobutamine hydrochloride (0.15-20 mg/kg; i.p.) results in subsequent increase in the left ventricular function and heart rate acceleration with an increasing dose in wildtype mice. Dobutamine hydrochloride results in significant inotropic, lusitropic, and chronotropic cardiac response with a high dose in wildtype mice. Low doses of Dobutamine hydrochloride significantly increases inotropic and lusitropic cardiac performance without chronotropic changes in the Tgαq*44 mice. Dobutamine hydrochloride increases heart rate only after high doses, but then inotropic and lusitropic cardiac functional reserve is lost. Dobutamine hydrochloride increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation.
参考文献:
1. Tuttle RR, et al. Dobutamine: development of a new catecholamine to selectively increase cardiac contractility. Circ Res. 1975 Jan;36(1):185-96. 2. Vallet B, et al. Dobutamine: mechanisms of action and use in acute cardiovascular pathology. Ann Cardiol Angeiol (Paris). 1991 Jun;40(6):397-402. 3. Tyrankiewicz U , et al. Characterization of the cardiac response to a low and high dose of dobutamine in the mouse model of dilated cardiomyopathy by MRI in vivo. J Magn Reson Imaging. 2013 Mar;37(3):669-77. 4. Tibayan FA, et al. Dobutamine increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation. Am J Respir Crit Care Med. 1997 Aug;156(2 Pt 1):438-44.
溶解性: DMSO  :  ≥  33  mg/mL  (97.68  mM)    H2O  :  20  mg/mL  (59.20  mM;  Need  ultrasonic)
保存条件: 2-8℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.96 ml 14.8 ml 29.6 ml
5 mM 0.592 ml 2.96 ml 5.92 ml
10 mM 0.296 ml 1.48 ml 2.96 ml
50 mM 0.059 ml 0.296 ml 0.592 ml
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参考文献

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