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• 产品描述： STO-609 is a selective and cell-permeable inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK), with Ki values of 80 and 15 ng/mL for recombinant CaM-KKα and CaM-KKβ, respectively. STO-609 inhibits AMP-activated protein kinase kinase (AMPKK) activity in HeLa cell lysates with an IC50 ~0.02 g/ml.

• 靶点： Ki: 80 ng/mL (CaM-KKα), 15 ng/mL (CaM-KKβ);CaMK;AMPK;Autophagy

• 参考文献：
  1. Tokumitsu H, et al. STO-609, a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase. J Biol Chem. 2002 May 3;277(18):15813-8. 2. Kukimoto-Niino M, et al. Crystal structure of the Ca2+/calmodulin-dependent protein kinase kinase in complex with the inhibitor STO-609. J Biol Chem. 2011 Jun 24;286(25):22570-9.

• 溶解性： DMSO  :  6.25  mg/mL  (19.89  mM;  ultrasonic  and  warming  and  heat  to  80°C)    DMF  :  5.56  mg/mL  (17.69  mM;  Need  ultrasonic)    H2O  :  <  0.1  mg/mL  (insoluble)

• 保存条件： 2-8℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	3.182 ml	15.909 ml	31.818 ml
  5 mM	0.636 ml	3.182 ml	6.364 ml
  10 mM	0.318 ml	1.591 ml	3.182 ml
  50 mM	0.064 ml	0.318 ml	0.636 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

• 2. [IF=8.786] Meijuan Meng et al."A high-concentrate diet induces inflammatory injury via regulating Ca2+/CaMKKβ-mediated autophagy in mammary gland tissue of dairy cows."Frontiers in Immunology.2023; 14: 1186170

• 1. [5.714] Meijuan Meng et al."β-carotene alleviates LPS-induced inflammation through regulating STIM1/ORAI1 expression in bovine mammary epithelial cells."INTERNATIONAL IMMUNOPHARMACOLOGY.2022 Dec;113:109377

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *