货号	规格	价格	上海	北京	武汉	南京
S80773-2mg	99.1%	￥240.00 S80773-2mg ￥240.00 现货	4 4	-	-	-
S80773-5mg	99.1%	￥400.00 S80773-5mg ￥400.00 现货	6 6	-	-	-
S80773-10mg	99.1%	￥640.00 S80773-10mg ￥640.00 现货	6 6	-	-	-
S80773-25mg	99.1%	￥960.00 S80773-25mg ￥960.00 现货	6 6	-	-	-
S80773-50mg	≥99%	￥1680.00 S80773-50mg ￥1680.00 2-3天	0 货期：2-3天	-	-	-
S80773-100mg	≥99%	￥3200.00 S80773-100mg ￥3200.00 2-3天	0 货期：2-3天	-	-	-

大包装询价收藏产品

加入购物车

产品介绍

CID755673 is a potent PKD inhibitor with IC50s of 182 nM, 280 nM and 227 nM for PKD1, PKD2 and PKD3, respectively.

产品描述：

CID755673 is a potent PKD inhibitor with IC50s of 182 nM, 280 nM and 227 nM for PKD1, PKD2 and PKD3, respectively.

靶点：

PKD1:182 nM (IC50);PKD3:227 nM (IC50);PKD2:280 nM (IC50);Serine/threoninkinase

体内研究：

Acute administration of the PKD inhibitor CID755673 to normal mice reduces both PKD1 and 2 phosphorylation in a time and dose-dependent manner. Chronic CID755673 administration to T2D db/db mice for two weeks reduces expression of the gene expression signature of PKD activation, enhances indices of both diastolic and systolic left ventricular function and is associated with reduced heart weight

参考文献：

1. Sharlow ER, et al. Potent and selective disruption of protein kinase D functionality by a benzoxoloazepinolone. J Biol Chem. 2008 Nov 28;283(48):33516-26. 2. Venardos K, et al. The PKD inhibitor CID755673 enhances cardiac function in diabetic db/db mice. PLoS One. 2015 Mar 23;10(3):e0120934.

溶解性：

DMSO : 100 mg/mL (460.36 mM; Need ultrasonic)

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	4.604 ml	23.018 ml	46.036 ml
5 mM	0.921 ml	4.604 ml	9.207 ml
10 mM	0.46 ml	2.302 ml	4.604 ml
50 mM	0.092 ml	0.46 ml	0.921 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置