| 产品描述： | CID755673 is a potent PKD inhibitor with IC50s of 182 nM, 280 nM and 227 nM for PKD1, PKD2 and PKD3, respectively. |
| 靶点： |
PKD1:182 nM (IC50);PKD3:227 nM (IC50);PKD2:280 nM (IC50);Serine/threoninkinase |
| 体内研究： |
Acute administration of the PKD inhibitor CID755673 to normal mice reduces both PKD1 and 2 phosphorylation in a time and dose-dependent manner. Chronic CID755673 administration to T2D db/db mice for two weeks reduces expression of the gene expression signature of PKD activation, enhances indices of both diastolic and systolic left ventricular function and is associated with reduced heart weight |
| 参考文献： |
1. Sharlow ER, et al. Potent and selective disruption of protein kinase D functionality by a benzoxoloazepinolone. J Biol Chem. 2008 Nov 28;283(48):33516-26. 2. Venardos K, et al. The PKD inhibitor CID755673 enhances cardiac function in diabetic db/db mice. PLoS One. 2015 Mar 23;10(3):e0120934. |
| 溶解性： |
DMSO : 100 mg/mL (460.36 mM; Need ultrasonic) |
| 保存条件： |
2-8℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
4.604 ml |
23.018 ml |
46.036 ml |
| 5 mM |
0.921 ml |
4.604 ml |
9.207 ml |
| 10 mM |
0.46 ml |
2.302 ml |
4.604 ml |
| 50 mM |
0.092 ml |
0.46 ml |
0.921 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京