货号	规格	价格	上海	北京	武汉	南京
S80804-1mg	98%	￥230.00 S80804-1mg ￥230.00 现货	8 2 8	1	1	-
S80804-2mg	98%	￥400.00 S80804-2mg ￥400.00 现货	11 2 >10	2	-	-
S80804-5mg	98%	￥720.00 S80804-5mg ￥720.00 现货	18 1 >10	1	-	-
S80804-10mg	98%	￥800.00 S80804-10mg ￥800.00 现货	11 >10	-	-	-
S80804-25mg	98%	￥1680.00 S80804-25mg ￥1680.00 现货	10 10	-	-	-
S80804-50mg	98%	￥3200.00 S80804-50mg ￥3200.00 现货	9 9	-	-	-
S80804-100mg	98%	￥4600.00 S80804-100mg ￥4600.00 现货	9 9	-	-	-

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产品介绍

Erastin is a ferroptosis inducer. Erastin binds and inhibits voltage-dependent anion channels (VDAC2/VDAC3)

产品溶液形式不稳定，建议现配现用。开封后保存请加封口膜和密封袋在干燥处保存。

产品描述：

Erastin is a ferroptosis inducer. Erastin binds and inhibits voltage-dependent anion channels (VDAC2/VDAC3)

产品溶液形式不稳定，建议现配现用。开封后保存请加封口膜和密封袋在干燥处保存。

靶点：

Ferroptosis;VDAC

体内研究：

Intraperitoneal injection of erastin at well-tolerated doses dramatically inhibits HT-29 xenograft growth in severe combined immunodeficient mice

参考文献：

1. Dixon SJ, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012 May 25;149(5):1060-72. 2. Xie Y, et al. Ferroptosis: process and function. Cell Death Differ. 2016 Mar;23(3):369-79. 3. Huo H, et al. Erastin Disrupts Mitochondrial Permeability Transition Pore (mPTP) and Induces Apoptotic Death of Colorectal Cancer Cells. PLoS One. 2016 May 12;11(5):e0154605.

溶解性：

DMSO : 12.5 mg/mL (22.85 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.828 ml	9.14 ml	18.28 ml
5 mM	0.366 ml	1.828 ml	3.656 ml
10 mM	0.183 ml	0.914 ml	1.828 ml
50 mM	0.037 ml	0.183 ml	0.366 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(14篇)

14. [IF=8.3] Zhenxin Guan et al."A Specific Targeted Enhanced Nanotherapy Strategy for Inducing Ferroptosis by Regulating the Iron Pool Levels in Tumor Cells."ACS Applied Materials & Interfaces.2024;XXXX(XXX):XXX-XXX 13. [IF=4.4] Mengjiao Xue et al."Curcumin nanocrystals ameliorate ferroptosis of diabetic nephropathy through glutathione peroxidase 4."Frontiers in Pharmacology.2025 Jan;15:1508312 12. [IF=5.7] He Jiani et al."Methyltransferase-like 7B participates in bladder cancer via ACSL3 m6A modification in a ferroptosis manner."Biology Direct.2025 Dec;20(1):1-15 11. [IF=14.7] Kexin Jia et al."Acteoside ameliorates hepatocyte ferroptosis and hepatic ischemia-reperfusion injury via targeting PCBP2."Acta Pharmaceutica Sinica B.2025 Mar;: 10. [IF=4] Yinhao ZHANG et al."Rehmanniae Radix Praeparata aqueous extract improves hepatic ischemia/reperfusion injury by restoring intracellular iron homeostasis."Chinese Journal of Natural Medicines.2024 Sep;22:769

9. [IF=3.1] Jing Xin et al."Melatonin mitigates the lipopolysaccharide-induced myocardial injury in rats by blocking the p53/xCT pathway-mediated ferroptosis."NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY.2024 Aug;:1-11 8. [IF=5.8] Muran Jiang et al."Copper oxide nanoparticles induce cuproptosis and ferroptosis through mitochondrial concatenation."Environmental Science-Nano.2024 Jul;: 7. [IF=5.3] Xue Xiaoyong et al."Si-Wu-Tang alleviates metabolic dysfunction-associated fatty liver disease by inhibiting ACSL4-mediated arachidonic acid metabolism and ferroptosis in MCD diet-fed mice."Chinese Medicine.2024 Dec;19(1):1-22 6. [IF=3.7] Xianqi Zhang et al."Salidroside induces mitochondrial dysfunction and ferroptosis to inhibit melanoma progression through reactive oxygen species production."EXPERIMENTAL CELL RESEARCH".2024 May;438:114034 5. [IF=4.7] Sheng Hu et al."Ginsenoside Rd enhances blood-brain barrier integrity after cerebral ischemia/reperfusion by alleviating endothelial cells ferroptosis via activation of NRG1/ErbB4-mediated PI3K/Akt/mTOR signaling pathway."NEUROPHARMACOLOGY".2024 Jun;251:1 4. [IF=3.8] Zhang Yunwen et al."Knockdown of SLC39A14 inhibits glioma progression by promoting erastin-induced ferroptosis SLC39A14 knockdown inhibits glioma progression."BMC CANCER.2023 Dec;23(1):1-15 3. [IF=3] Zhang Meixia et al."NFE2L1 restrains ferroptosis by transcriptionally regulating HJURP and participates in the progress of oral squamous cell carcinoma."JOURNAL OF BIOENERGETICS AND BIOMEMBRANES.2023 Oct;:1-12 2. [IF=4.831] Ying Lan et al."Polysiloxane-based hyperbranched fluorescent probe for dynamic visualization of HClO in lysosomes and vivo."SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY.2023 Jun;294:122527 1. [IF=6.313] Yijia Yang et al."Piperlongumine Inhibits Thioredoxin Reductase 1 by Targeting Selenocysteine Residues and Sensitizes Cancer Cells to Erastin."Antioxidants-Basel. 2022 Apr;11(4):710

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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浓度

体积

分子摩尔量

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Erastin