| 产品描述： | KU-55933 is a potent ATM inhibitor with an IC50 and Ki of 12.9 and 2.2 nM, respectively, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR. |
| 靶点： |
ATM:12.9 nM (IC50);DNA-PK:2500 nM (IC50);mTOR:9300 nM (IC50);PI3K:16600 nM (IC50) |
| 参考文献： |
1. Hickson I, et al. Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res. 2004 Dec 15;64(24):9152-9 2. Khalil HS, et al. Pharmacological inhibition of ATM by KU55933 stimulates ATM transcription.Exp Biol Med (Maywood). 2012 Jun;237(6):622-34. Epub 2012 Jun 22. 3. Kim YD, et al. Orphan nuclear receptor SHP negatively regulates growth hormone-mediated induction of hepatic gluconeogenesis through inhibition of STAT5 transactivation.J Biol Chem. 2012 Sep 12. |
| 溶解性： |
DMSO : 80 mg/mL (202.28 mM; Need ultrasonic) |
| 保存条件： |
-20℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.529 ml |
12.643 ml |
25.285 ml |
| 5 mM |
0.506 ml |
2.529 ml |
5.057 ml |
| 10 mM |
0.253 ml |
1.264 ml |
2.529 ml |
| 50 mM |
0.051 ml |
0.253 ml |
0.506 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京