TWS119 98%

TWS119

源叶(MedMol)
S80825
601514-19-6
C18H14N4O2
318.33
3-(6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenol
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶(MedMol) S80825-2mg 98% ¥212.50元 9 - - -
源叶(MedMol) S80825-5mg 98% ¥340.00元 5 - - -
源叶(MedMol) S80825-10mg 98% ¥595.00元 7 - - -
源叶(MedMol) S80825-25mg 98% ¥1275.00元 5 - - -
源叶(MedMol) S80825-50mg 98% ¥2380.00元 预计交期:2-3天 - - -
源叶(MedMol) S80825-100mg 98% ¥3910.00元 预计交期:2-3天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

TWS119 is a specific inhibitor of GSK-3β, with an IC50 of 30 nM, and activates the wnt/β-catenin pathway.
产品描述: TWS119 is a specific inhibitor of GSK-3β, with an IC50 of 30 nM, and activates the wnt/β-catenin pathway.
靶点: GSK-3β:30 nM (IC50);GSK-3;Autophagy
体内研究: TWS119 (30 mg/kg, i.p.) improves the neurologic function and decreases neurologic deficit dcore in rtPA-treated MCAO rats. TWS119 effectively relieves cerebral edema, and reduces cerebral infarction in rats treated with rtPA. TWS119 also effectively decreases blood-brain barrier permeability in rtPA-Treated MCAO Rats and attenuates rtPA-induced hemorrhage in ischemic brain tissue. Futhermore, TWS119 activates the Wnt/β-Catenin signaling pathway and increases the expression of Claudin-3 and ZO-1
参考文献: 1. Ding S, et al. Synthetic small molecules that control stem cell fate. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7632-7. Epub 2003 Jun 6. 2. Wang W, et al. GSK-3β inhibitor TWS119 attenuates rtPA-induced hemorrhagic transformation and activates the Wnt/β-catenin signaling pathway after acute ischemic stroke in rats. Mol Neurobiol. 2016 Dec;53(10):7028-7036. Epub 2015 Dec 15. 3. Chen YQ, et al. Wnt pathway activator TWS119 enhances the proliferation and cytolytic activity of human γδT cells against colon cancer. Exp Cell Res. 2017 Nov 16. pii: S0014-4827(17)30587-6.
溶解性: Soluble  in  DMSO
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 3.141 ml 15.707 ml 31.414 ml
5 mM 0.628 ml 3.141 ml 6.283 ml
10 mM 0.314 ml 1.571 ml 3.141 ml
50 mM 0.063 ml 0.314 ml 0.628 ml
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参考文献

质检证书(COA)

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摩尔浓度计算器

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