| 品牌 | 货号 | 产品规格 | 价格(RMB) | 库存（上海） | 北京 | 武汉 | 南京 | 购买数量 |
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| 源叶(MedMol) | S80884-5mg | 99% | ￥220.00元 | >10 | - | - | - |
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| 源叶(MedMol) | S80884-10mg | 99% | ￥420.00元 | >10 | - | - | - |
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| 源叶(MedMol) | S80884-50mg | 99% | ￥1470.00元 | >10 | - | - | - |
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Fenoldopam mesylate (SKF-82526) is a D1 receptor agonist and a novel lysine-specific demethylase 1 (LSD1) inhibitor (IC50=0.8974 μM). Fenoldopam mesylate shows anti-hypertensive effects, anti-cancer cell proliferation activity and can induce cells apoptosis
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产品描述： Fenoldopam mesylate (SKF-82526) is a D1 receptor agonist and a novel lysine-specific demethylase 1 (LSD1) inhibitor (IC50=0.8974 μM). Fenoldopam mesylate shows anti-hypertensive effects, anti-cancer cell proliferation activity and can induce cells apoptosis | ||||||||||||||||||||
| 靶点： IC50: 0.8974 μM (LSD1);DopamineReceptor | ||||||||||||||||||||
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体内研究： Fenoldopam mesylate (subcutaneous injection; 100 mg/kg; once daily; 2 d) can induce arteritis in rats detected by magnetic resonance imaging (MRI) |
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参考文献： 1. A Grenader, et al. Fenoldopam is a partial agonist at dopamine-1 (DA1) receptors in LLC-PK1 cells. J Pharmacol Exp Ther. 1991 Jul 1;258(1):193-8. 2. Yan Zheng, et al. Identification of fenoldopam as a novel LSD1 inhibitor to abrogate the proliferation of renal cell carcinoma using drug repurposing strategy. Bioorg Chem. 2021 Mar;108:104561. 3. Yuta Fujii, et al. Detection of fenoldopam-induced arteritis in rats using ex vivo / in vivo MRI. Toxicology Reports, Volume 9, 2022, Pages 1595-1602. |
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| 溶解性： Soluble in DMSO、H2O | ||||||||||||||||||||
| 保存条件： RT | ||||||||||||||||||||
配置溶液浓度参考：
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