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Alarelin (Acetate) 99%

Alarelin (Acetate)

源叶(MedMol)
S80954
79561-22-1
C60H86N16O16
1287.422
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶(MedMol) S80954-5mg 99% ¥200.00元 9 - - -
源叶(MedMol) S80954-10mg 99% ¥310.00元 9 - - -
源叶(MedMol) S80954-50mg 99% ¥620.00元 6 - - -
源叶(MedMol) S80954-100mg 99% ¥990.00元 4 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

Alarelin acetate is a synthetic GnRH agonist which can directly inhibit proliferation and DNA synthesis of rat GSMC through GnRH receptors.
产品描述: Alarelin acetate is a synthetic GnRH agonist which can directly inhibit proliferation and DNA synthesis of rat GSMC through GnRH receptors.
靶点: GNRH Receptor;GNRHReceptor
体外研究:
The cell viability in the presence of alarelin was significantly lower compared to in the absence of alarelin. The maximum stimulatory effect on cell viability was achieved at a concentration of 10-5 M and it acted in a dose-dependent manner
体内研究:
Alarelin could inhibit the gastric acid secretion both by direct actions on parietal cells in rats and by inhibiting vagous function[2]. Alarelin could markedly increase the ratio of G1 phase and decrease ratio of S phase of GSMC of rats
细胞实验: The cells are trypsinized in a solution of 2.5 g/L trypsin and seeded in a 96-well plate. After the cells are grown for 24 h to approximately 800 g/L subconfluent state, 0.1 mL medium containing 2.5% calf serum and various concentrations (0.001, 0.1, 10 μM) of alarelin is added to each well, respectively, and incubated for 24 h in a CO2 incubator. Each concentration is tested in at least 12 wells. Briefly, 15 μL of MTT solution is added to each well and incubated for 4 h. Then, the medium and MTT are removed and 150 μL of DMSO is added to each well and shaken for 10 min to dissolve the crystal. The OD is determined at 490 nm using an ELISA reader
参考文献:
1. Chen L, et al. Distribution, cloning and sequencing of GnRH, its receptor, and effects of gastric acid secretion of GnRH analogue in gastric parietal cells of rats. Life Sci. 2005 Feb 4;76(12):1351-65. 2. Chen L, et al. Expression of gonadotropin-releasing hormone receptor and effect of gonadotropin-releasing hormone analogue on proliferation of cultured gastric smooth muscle cells of rats. World J Gastroenterol. 2004 Jun 15;10(12):1780-4.
溶解性: soluble  in  DMSO
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 0.777 ml 3.884 ml 7.767 ml
5 mM 0.155 ml 0.777 ml 1.553 ml
10 mM 0.078 ml 0.388 ml 0.777 ml
50 mM 0.016 ml 0.078 ml 0.155 ml
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参考文献

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