BIIB021

    98%

BIIB021

源叶(MedMol)
S80993
848695-25-0
C14H15ClN6O
318.77
CNF2024;6-chloro-9-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-9H-purin-2-amine
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶(MedMol) S80993-5mg 98% ¥116.00元 10 - - -
源叶(MedMol) S80993-25mg 98% ¥350.00元 8 - - -
源叶(MedMol) S80993-50mg 98% ¥500.00元 6 - - -
源叶(MedMol) S80993-100mg 98% ¥700.00元 1 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

BIIB021 (CNF2024) is an orally active, fully synthetic inhibitor of HSP90 with a Ki and an EC50 of 1.7 nM and 38 nM, respectively
产品描述: BIIB021 (CNF2024) is an orally active, fully synthetic inhibitor of HSP90 with a Ki and an EC50 of 1.7 nM and 38 nM, respectively
靶点: HSP90:1.7 nM (Ki);HSP90:38 nM (EC50);HSP;Autophagy
体内研究: Oral administration of BIIB021 leads to tumor growth inhibition in many tumor xenograft models including N87, BT474, CWR22, U87, SKOV3 and Panc-1. BIIB021 effectively inhibits growth of L540cy tumor at a dose of 120 mg/kg. BIIB021 significantly enhances antitumor growth effect of radiation in JHU12 xenograf].
参考文献: 1. Lundgren, Karen., et al. BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90. Molecular Cancer Therapeutics (2009), 8(4), 921-929. 2. B?ll B, et al. Heat shock protein 90 inhibitor BIIB021 (CNF2024) depletes NF-kappaB and sensitizes Hodgkin's lymphoma cells for natural killer cell-mediated cytotoxicity. Clin Cancer Res. 2009 Aug 15;15(16):5108-16. 3. Yin X, et al. BIIB021, a novel Hsp90 inhibitor, sensitizes head and neck squamous cell carcinoma to radiotherapy. Int J Cancer. 2010 Mar 1;126(5):1216-25 4. Zhang H, et al. BIIB021, a synthetic Hsp90 inhibitor, has broad application against tumors with acquired multidrug resistance. Int J Cancer. 2010 Mar 1;126(5):1226-34
溶解性: DMSO  :  ≥  45  mg/mL  (141.17  mM)
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 3.137 ml 15.685 ml 31.371 ml
5 mM 0.627 ml 3.137 ml 6.274 ml
10 mM 0.314 ml 1.569 ml 3.137 ml
50 mM 0.063 ml 0.314 ml 0.627 ml
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参考文献

质检证书(COA)

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