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S81009

BML-284

源叶(MedMol) 98%
  • 英文名:
  • BML-284
  • 别名:
  • CAS号:
  • 853220-52-7
  • 分子式:
  • C19H18N4O3
  • 分子量:
  • 350.3712
  • 核磁/质谱:
品牌货号产品规格价格(RMB) 库存(上海) 北京 武汉 南京 数量计量单位 加入购物车...
源叶(MedMol) S81009-5mg 98% ¥384.00元 10 - - - EA 加入购物车
源叶(MedMol) S81009-10mg 98% ¥600.00元 9 - - - EA 加入购物车
源叶(MedMol) S81009-50mg 98% ¥1920.00元 5 - - - EA 加入购物车
源叶(MedMol) S81009-100mg 98% ¥3360.00元 预计交期:2-3天 - - - EA 加入购物车
源叶(MedMol) S81009-200mg 98% ¥5360.00元 预计交期:2-3天 - - - EA 加入购物车
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参考文献

质检证书(COA)

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  • 提示:详情请下载说明书。
  • 产品描述: BML-284 is a potent and cell-permeable Wnt signaling activator. BML-284 induces TCF-dependent transcriptional activity with an EC50 of 700 nM
  • 靶点: EC50: 700 nM (TCF-dependent transcriptional activity);Wnt/beta-catenin
  • 体外研究:
    BML-284 (10 µM; 24 hours) significantly increases the migration and invasion of both MNK45 and AGS cells and partially restores the migratory and invasive abilities of cells inhibited by pizotifen. BML-284 (10 µM; 24 hours) induces the expression of β-catenin significantly when compared with the NC group. It also partially reverses the effects induced by pizotifen on E-cadherin and N-cadherin expression in MNK45 and AGS cells compared with the pizotifen-treated group. Western Blot Analysis Cell Line: Human gastric cancer cell lines MNK45 and AGS Concentration: 10 µM Incubation Time: 24 hours Result: Induced β-catenin expression and reserved E-cadherin and N-cadherin expression in MNK45 and AGS cells.
  • 体内研究:
    BML-284 (10 ng) combines with Pyrimethanil (4 mg/L) could partially rescue the malformed phenotype and cardiac defects induced by Pyrimethanil in Tg (myl7:EGFP) transgenic embryos at 5.5 hpf are transferred into plates with 20 embryos
  • 参考文献:
    1. Liu J, et al. A small-molecule agonist of the Wnt signaling pathway. Angew Chem Int Ed Engl. 2005 Mar 18;44(13):1987-90. 2. Ying Jiang, et al. Pizotifen inhibits the proliferation and invasion of gastric cancer cells. Exp Ther Med. 2020 Feb;19(2):817-824. 3. Yunlong Meng, et al. Exposure to pyrimethanil induces developmental toxicity and cardiotoxicity in zebrafish. Chemosphere. 2020 Sep;255:126889.
  • 溶解性: soluble  in  DMSO
  • 保存条件: -20℃
  • 配置溶液浓度参考:
    1mg 5mg 10mg
    1 mM 2.854 ml 14.271 ml 28.541 ml
    5 mM 0.571 ml 2.854 ml 5.708 ml
    10 mM 0.285 ml 1.427 ml 2.854 ml
    50 mM 0.057 ml 0.285 ml 0.571 ml
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