| 产品描述： | (-)-Blebbistatin is a selective inhibitor of the ATPase activity of non-muscle myosin II |
| 靶点： |
IC50: 0.5 to 5 μM (myosin II);ATPase; Myosin |
| 体内研究： |
Blebbistatin dose-dependently and completely relax both KCl- and carbachol-induced rat detrusor and endothelin-1-induced human bladder contraction. Pre-incubation with 10 μM blebbistatin attenuates carbachol responsiveness by 65% while blocking electrical field stimulation-induced bladder contraction reaching 50% inhibition at 32 Hz |
| 参考文献： |
1. Cristina Lucas‐Lopez, et al. Absolute Stereochemical Assignment and Fluorescence Tuning of the Small Molecule Tool, (–)‐Blebbistatin. 2. Ponsaerts R, et al. The myosin II ATPase inhibitor blebbistatin prevents thrombin-induced inhibition of intercellularcalcium wave propagation in corneal endothelial cells. Invest Ophthalmol Vis Sci. 2008 Nov;49(11):4816-27. |
| 溶解性： |
DMSO : 10 mg/mL (34.21 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble) |
| 保存条件： |
-20℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
3.421 ml |
17.104 ml |
34.208 ml |
| 5 mM |
0.684 ml |
3.421 ml |
6.842 ml |
| 10 mM |
0.342 ml |
1.71 ml |
3.421 ml |
| 50 mM |
0.068 ml |
0.342 ml |
0.684 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京