Ivacaftor (VX-770) 99%

Ivacaftor (VX-770)

源叶(MedMol)
S81045
873054-44-5
C24H28N2O3
392.49
VX 770;N-(2,4-二叔丁基-5-羟基苯基)-1,4-二氢-4-氧代-3-喹啉甲酰胺
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶(MedMol) S81045-5mg 99% ¥50.00元 >10 - - -
源叶(MedMol) S81045-10mg 99% ¥75.00元 >10 - - -
源叶(MedMol) S81045-50mg 99% ¥170.00元 >10 - - -
源叶(MedMol) S81045-250mg 99% ¥570.00元 >10 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

Ivacaftor (VX-770) is a potent and orally bioavailable CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC50s of 100 nM and 25 nM, respectively.
产品描述: Ivacaftor (VX-770) is a potent and orally bioavailable CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC50s of 100 nM and 25 nM, respectively.
靶点: EC50: 100 nM (G551D-CFTR), 25 nM (F508del-CFTR);CFTR; Autophagy
体内研究: Ivacaftor (1-200 mg/kg, p.o.) exhibits good oral bioavailability in rat
参考文献: 1. Delaunay JL, et al. Functional defect of variants in the adenosine triphosphate-binding sites of ABCB4 and their rescue by the cystic fibrosis transmembrane conductance regulator potentiator, ivacaftor (VX-770). Hepatology. 2017 Feb;65(2):560-570 2. Mutyam V, et al. Therapeutic benefit observed with the CFTR potentiator, ivacaftor, in a CF patient homozygous for the W1282X CFTR nonsense mutation. J Cyst Fibros. 2017 Jan;16(1):24-29 3. Hadida S, et al. Discovery of N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, ivacaftor), a potent and orally bioavailable CFTR potentiator. J Med Chem. 2014 Dec 11;57(23):9776-9 4. Van Goor F, et al. Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18825-30.
溶解性: Soluble  in  DMSO
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.548 ml 12.739 ml 25.478 ml
5 mM 0.51 ml 2.548 ml 5.096 ml
10 mM 0.255 ml 1.274 ml 2.548 ml
50 mM 0.051 ml 0.255 ml 0.51 ml
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参考文献

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