S81147 |
CCT129202 |
源叶(MedMol) | ≥99% |
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- 产品描述: CCT129202 is an aurora kinase inhibitor with IC50s of 42, 198, and 227 nM for aurora A, B and C, respectively.
- 靶点: Aurora A:42 nM (IC50);Aurora B:198 nM (IC50);Aurora C:227 nM (IC50);AuroraKinase
- 体内研究:
Growth of HCT116 xenografts in nude mice is inhibited after i.p. administration of CCT129202. p21, the cyclin-dependent kinase inhibitor, is induced by CCT129202. Up-regulation of p21 by CCT129202 in HCT116 cells led to Rb hypophosphorylation and E2F inhibition, contributing to a decrease in thymidine kinase 1 transcription
- 参考文献:
1. Chan F, et al. Mechanism of action of the Aurora kinase inhibitor CCT129202 and in vivo quantification of biological activity. Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3147-57.
- 溶解性: Soluble in DMSO
- 保存条件: -20°C
- 配置溶液浓度参考:
1mg 5mg 10mg 1 mM 2.012 ml 10.06 ml 20.12 ml 5 mM 0.402 ml 2.012 ml 4.024 ml 10 mM 0.201 ml 1.006 ml 2.012 ml 50 mM 0.04 ml 0.201 ml 0.402 ml
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)