| 产品描述： | Salmeterol (GR 33343X) xinafoate is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively |
| 靶点： |
β2 adrenoceptor:9.6 (pEC50);β1 adrenoceptor:6.1 (pEC50);β3 adrenoceptor:5.9 (pEC50);HIVProtease; AdrenergicReceptor |
| 体内研究： |
Salmeterol (0.16 mg/kg), Formoterol (0.32 mg/kg) and combined treatment have therapeutic effects in mice with chronic obstructive pulmonary disease (COPD) |
| 参考文献： |
1. Panayiotis A Procopiou, et al. The discovery of long-acting saligenin β₂ adrenergic receptor agonists incorporating a urea group. Bioorg Med Chem. 2011 Oct 15;19(20):6026-32. 2. Malcolm Johnson. Effects of beta2-agonists on resident and infiltrating inflammatory cells. J Allergy Clin Immunol. 2002 Dec;110(6 Suppl):S282-90. 3. Zhiyuan Wang, et al. Efficacy of salmeterol and formoterol combination treatment in mice with chronic obstructive pulmonary disease. Exp Ther Med. 2018 Feb;15(2):1538-1545. |
| 溶解性： |
DMSO : ≥ 50 mg/mL (82.82 mM) |
| 保存条件： |
2-8℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
1.656 ml |
8.282 ml |
16.563 ml |
| 5 mM |
0.331 ml |
1.656 ml |
3.313 ml |
| 10 mM |
0.166 ml |
0.828 ml |
1.656 ml |
| 50 mM |
0.033 ml |
0.166 ml |
0.331 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京