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S81172

Dapagliflozin ((2S)-1,2-propanediol, hydrate)

源叶(MedMol) 99%
  • 英文名:
  • Dapagliflozin ((2S)-1,2-propanediol, hydrate)
  • 别名:
  • CAS号:
  • 960404-48-2
  • 分子式:
  • C24H35ClO9
  • 分子量:
  • 502.9823
  • 核磁/质谱:
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源叶(MedMol) S81172-5mg 99% ¥510.00元 >10 - - - EA 加入购物车
源叶(MedMol) S81172-10mg 99% ¥765.00元 >10 - - - EA 加入购物车
源叶(MedMol) S81172-50mg 99% ¥1530.00元 >10 - - - EA 加入购物车
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  • 产品描述: Dapagliflozin propanediol belongs to the class of orally administered antidiabetic agents designated as sodiumglucose cotransporter 2 (SGLT2) inhibitors
  • 靶点: SGLT2;SGLT
  • 体外研究:
    Dapagliflozin is a small-molecule inhibitor of SGLT2 that has been shown to be highly selective for SGLT2 compared with other SGLT family members and to have no off-target interactions in an in vitro screen of more than 330 receptors, enzymes, ion channels, and transporters
  • 体内研究:
    Dapagliflozin demonstrates good oral bioavailability, has a high volume of distribution, and has an in vivo metabolite profile that is qualitatively similar between preclinical species and humans. Both non-clinical and clinical assessments have shown dapagliflozin to have a highly favorable safety profile that is consistent with its simple mechanism of action, with no off-target effects observed
  • 动物实验: Animal Models: Sprague-Dawley (SD) rats Dosages: 25, 100, 150, or 200 mg/kg Administration: oral
  • 参考文献:
    1. Reilly TP, et al. Carcinogenicity risk assessment supports the chronic safety of dapagliflozin, an inhibitor of sodium-glucose co-transporter 2, in the treatment of type 2 diabetes mellitus. Diabetes Ther. 2014, 5(1):73-96.
  • 溶解性: Soluble  in  DMSO、Ethanol
  • 保存条件: -20℃
  • 配置溶液浓度参考:
    1mg 5mg 10mg
    1 mM 1.988 ml 9.941 ml 19.881 ml
    5 mM 0.398 ml 1.988 ml 3.976 ml
    10 mM 0.199 ml 0.994 ml 1.988 ml
    50 mM 0.04 ml 0.199 ml 0.398 ml
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