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S81173

MPEP

源叶(MedMol) 98%
  • 英文名:
  • MPEP
  • 别名:
  • 2-甲基-6-(苯乙炔)吡啶盐酸盐;2-methyl-6-(2-phenylethynyl)pyridine
  • CAS号:
  • 96206-92-7
  • 分子式:
  • C14H11N
  • 分子量:
  • 193.24
  • 核磁/质谱:
品牌货号产品规格价格(RMB) 库存(上海) 北京 武汉 南京 数量计量单位 加入购物车...
源叶(MedMol) S81173-10mg 98% ¥54.00元 10 - - - EA 加入购物车
源叶(MedMol) S81173-50mg 98% ¥87.00元 8 - - - EA 加入购物车
源叶(MedMol) S81173-250mg 98% ¥335.00元 6 - - - EA 加入购物车
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  • 提示:详情请下载说明书。
  • 产品描述: MPEP is a potent, selective, noncompetitive, orally active and systemically active mGlu5 receptor antagonist, with an IC50 of 36 nM for completely inhibiting quisqualate-stimulated phosphoinositide (PI) hydrolysis. MPEP has anxiolytic-or antidepressant-like effects
  • 靶点: mGluR5:36 nM (IC50);GluR
  • 体内研究:
    MPEP (1-30 mg/kg) induces anxiolytic-like effects in the conflict drinking test and the elevated plus-maze test in rats as well as in the four-plate test in mice. MPEP (1-20 mg/kg) does shorten the immobility time in a tail suspension test in mice, however it is inactive in the behavioural despair test in rats. MPEP (30 mg/kg i.p.) slightly but significantly increases (by 39%) the number of punished crossings in the four-plate test, lower doses of the compound (3 and 10 mg/kg) does not affect the number of punished crossings in that test (F (3,36)=3.240, P<0.05). MPEP (1, 10 and 20 mg/kg) significantly (by 55% after the highest dose), (F(3,28)=15.47, P<0.001) decreases the immobility time of mice in the tail suspension test. Its efficacy is similar to that of imipramine (20 mg/kg), used as the positive standard.
  • 参考文献:
    1. F Gasparini, et al. 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a Potent, Selective and Systemically Active mGlu5 Receptor Antagonist. Neuropharmacology. 1999 Oct;38(10):1493-503. 2. E Tatarczyńska, et al. Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist. Br J Pharmacol. 2001 Apr;132(7):1423-30.
  • 溶解性: DMSO  :  100  mg/mL  (517.49  mM;  Need  ultrasonic)
  • 保存条件: -20℃
  • 配置溶液浓度参考:
    1mg 5mg 10mg
    1 mM 5.175 ml 25.875 ml 51.749 ml
    5 mM 1.035 ml 5.175 ml 10.35 ml
    10 mM 0.517 ml 2.587 ml 5.175 ml
    50 mM 0.103 ml 0.517 ml 1.035 ml
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