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• 产品描述： LDC000067 is a highly specific CDK9 inhibitor with an IC50 value of 44±10 nM in vitro.

• 靶点： CDK9- Cyclin T1:44 nM (IC50);cdk2-cyclin A;2441 nM (IC50);cdk1-cyclin B1:5513 nM (IC50);cdk4-cyclin D1:9242 nM (IC50);GSK3A:1460 nM (IC50);HGK/MAP4K4:820 nM (IC50);ABL2/ARG:3640 nM (IC50);Apoptosis; CDK

• 体外研究：
  The selectivity of LDC000067 for CDK9 over other CDKs exceeds that of the known inhibitors flavopiridol and DRB. LDC000067 displayed 55/125/210/ >227/ >227-fold selectivity for CDK9 versus CDK2/1/4/6/7. LDC000067 inhibits in vitro transcription in an ATP-competitive and dose-dependent manner. Gene expression profiling of cells treated with LDC000067 demonstrates a selective reduction of short-lived mRNAs, including important regulators of proliferation and apoptosis

• 参考文献：
  1. Albert TK, et al. Characterization of molecular and cellular functions of the cyclin-dependent kinase CDK9 using a novel specific inhibitor. Br J Pharmacol. 2014 Jan;171(1):55-68.

• 溶解性： soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.7 ml	13.498 ml	26.996 ml
  5 mM	0.54 ml	2.7 ml	5.399 ml
  10 mM	0.27 ml	1.35 ml	2.7 ml
  50 mM	0.054 ml	0.27 ml	0.54 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *