产品描述: | PF-04418948 is an orally active, potent and selective prostaglandin EP2 receptor antagonist with an IC50 of 16 nM |
靶点: |
Prostaglandin Receptor;ProstaglandinReceptor |
体内研究: |
PF-04418948 (oral gavage; 1, 3, and 10 mg/kg; once) attenuats the butaprost-induced cutaneous blood flow response |
参考文献: |
1. af Forselles KJ, et al. In vitro and in vivo characterization of PF-04418948, a novel, potent and selective prostaglandin EP2 receptor antagonist. Br J Pharmacol. 2011 Dec;164(7):1847-1856. 2. Birrell MA, et al. Selectivity profiling of the novel EP2 receptor antagonist, PF-04418948, in functional bioassay systems: atypical affinity at the guinea pig EP2 receptor. Br J Pharmacol. 2013 Jan;168(1):129-138. |
溶解性: |
DMSO : 130 mg/mL (317.53 mM; Need ultrasonic) |
保存条件: |
-20℃ |
配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
1 mM |
2.443 ml |
12.213 ml |
24.426 ml |
5 mM |
0.489 ml |
2.443 ml |
4.885 ml |
10 mM |
0.244 ml |
1.221 ml |
2.443 ml |
50 mM |
0.049 ml |
0.244 ml |
0.489 ml |
|
注意: |
部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。 |