| 产品描述： | PF-04418948 is an orally active, potent and selective prostaglandin EP2 receptor antagonist with an IC50 of 16 nM |
| 靶点： |
Prostaglandin Receptor;ProstaglandinReceptor |
| 体内研究： |
PF-04418948 (oral gavage; 1, 3, and 10 mg/kg; once) attenuats the butaprost-induced cutaneous blood flow response |
| 参考文献： |
1. af Forselles KJ, et al. In vitro and in vivo characterization of PF-04418948, a novel, potent and selective prostaglandin EP2 receptor antagonist. Br J Pharmacol. 2011 Dec;164(7):1847-1856. 2. Birrell MA, et al. Selectivity profiling of the novel EP2 receptor antagonist, PF-04418948, in functional bioassay systems: atypical affinity at the guinea pig EP2 receptor. Br J Pharmacol. 2013 Jan;168(1):129-138. |
| 溶解性： |
DMSO : 130 mg/mL (317.53 mM; Need ultrasonic) |
| 保存条件： |
-20℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.443 ml |
12.213 ml |
24.426 ml |
| 5 mM |
0.489 ml |
2.443 ml |
4.885 ml |
| 10 mM |
0.244 ml |
1.221 ml |
2.443 ml |
| 50 mM |
0.049 ml |
0.244 ml |
0.489 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京