产品描述: Salermide is an inhibitor of Sirt1 and Sirt2; can cause strong cancer-specific apoptotic cell death. |
靶点:
SIRT1;SIRT2;Apoptosis; Sirtuin |
体内研究:
Salermide is well tolerated by mice at concentrations up to 100 μM. Salermide's mechanism of action in vivo is specifically mediated by Sirt1. Intraperitoneal feeding of Salermide has no apparent toxicity in nude mice |
参考文献:
1. Lara E, et al. Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect. Oncogene. 2009 Feb 12;28(6):781-91. |
溶解性:
DMSO : ≥ 50 mg/mL (126.75 mM) |
保存条件:
-20℃ |
配置溶液浓度参考:
|
1mg |
5mg |
10mg |
1 mM |
2.535 ml |
12.675 ml |
25.351 ml |
5 mM |
0.507 ml |
2.535 ml |
5.07 ml |
10 mM |
0.254 ml |
1.268 ml |
2.535 ml |
50 mM |
0.051 ml |
0.254 ml |
0.507 ml |
|
注意: |
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