AZD5363 97%

4-Piperidinecarboxamide, 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-

源叶(MedMol)
S81216
1143532-39-1
C21H25ClN6O2
428.92
UNII-WFR23M21IE; CS-1284; AZD5363;
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶(MedMol) S81216-1mg 97% ¥149.60元 3 - - -
源叶(MedMol) S81216-2mg 97% ¥272.00元 >10 - - -
源叶(MedMol) S81216-5mg 97% ¥430.00元 5 - - -
源叶(MedMol) S81216-10mg 97% ¥600.00元 4 - - -
源叶(MedMol) S81216-25mg 97% ¥720.00元 6 - - -
源叶(MedMol) S81216-50mg 97% ¥1150.00元 7 - - -
源叶(MedMol) S81216-100mg 97% ¥1840.00元 5 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

Capivasertib (AZD5363) is an orally active and potent pan-AKT kinase inhibitor with IC50 of 3, 7 and 7 nM for Akt1,Akt2 and Akt3, respectively.
产品描述: Capivasertib (AZD5363) is an orally active and potent pan-AKT kinase inhibitor with IC50 of 3, 7 and 7 nM for Akt1,Akt2 and Akt3, respectively.
靶点: Akt1:3 nM (IC50);Akt2:7 nM (IC50);Akt3:7 nM (IC50);ROCK2:60 nM (IC50);ROCK1:470 nM (IC50);PKA:7 nM (IC50);P70S6K:6 nM (IC50);Autophagy;Akt; PKA; mTOR; Autophagy
体内研究: Oral dosing of Capivasertib (AZD5363) to nude mice causes dose- and time-dependent reduction of PRAS40, GSK3β, and S6 phosphorylation in BT474c xenografts (PRAS40 phosphorylation EC50 ~0.1 μM total plasma exposure), reversible increases in blood glucose concentrations, and dose-dependent decreases in 2[18F]fluoro-2-deoxy-D-glucose (18F-FDG) uptake in U87-MG xenografts. Chronic oral dosing of Capivasertib caused dose-dependent growth inhibition of xenografts derived from various tumor types, including HER2+ breast cancer models. Capivasertib also significantly enhances the antitumor activity of RP-56976 and GW572016 in breast cancer xenografts
参考文献: 1. Davies BR, et al. Preclinical pharmacology of AZD5363, an inhibitor of AKT: pharmacodynamics, antitumor activity, and correlation of monotherapy activity with genetic background. Mol Cancer Ther. 2012 Apr;11(4):873-87.
溶解性: DMSO  :  125  mg/mL  (291.43  mM;  Need  ultrasonic)
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.331 ml 11.657 ml 23.314 ml
5 mM 0.466 ml 2.331 ml 4.663 ml
10 mM 0.233 ml 1.166 ml 2.331 ml
50 mM 0.047 ml 0.233 ml 0.466 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

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