| 产品描述： | MRT67307 is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively. MRT67307 also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 also blocks autophagy in cells |
| 靶点： |
TBK1:19 nM (IC50, at 0.1 mM ATP);IKKε:160 nM (IC50, at 0.1 mM ATP);ULK2:38 nM (IC50);ULK1:45 nM (IC50);Autophagy;IκB/IKK; Autophagy |
| 参考文献： |
1. Clark K, et al. Novel cross-talk within the IKK family controls innate immunity. Biochem J. 2011 Feb 15;434(1):93-104. 2. Petherick KJ, et al. Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy. J Biol Chem. 2015 May 1;290(18):11376-83. 3. Zhu Z, et al. Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit. 26.37Cancer Discov. 2014 Apr;4(4):452-65. |
| 溶解性： |
DMSO : ≥ 100 mg/mL (215.24 mM) |
| 保存条件： |
-20℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.152 ml |
10.762 ml |
21.524 ml |
| 5 mM |
0.43 ml |
2.152 ml |
4.305 ml |
| 10 mM |
0.215 ml |
1.076 ml |
2.152 ml |
| 50 mM |
0.043 ml |
0.215 ml |
0.43 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京