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RSL3

    
99.3%

RSL3

源叶(MedMol)
S81241 一键复制产品信息
1219810-16-8
C23H21ClN2O5
货号 规格 价格 上海 北京 武汉 南京 购买数量
S81241-1mg
99.3% ¥320.00 >10 - - -
S81241-2mg
99.3% ¥600.00 4 - - -
S81241-5mg
99.3% ¥980.00 7 - - -
S81241-10mg
99.3% ¥1800.00 4 - - -
S81241-25mg
99.3% ¥2400.00 4 - - -
S81241-50mg
99.3% ¥4000.00 1 - - -
S81241-100mg
99.3% ¥6000.00 1 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells

产品描述: RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells
靶点: Glutathione peroxidase 4;Ferroptosis; GPX; GlutathionePeroxidase
体内研究: RSL3 (100 mg/kg, Intratumorally twice per week for 20 days) significantly inhibits the growth of tumor in combination with trigonelline in mice bearing HN3R cells.
参考文献: 1. Shin D, et al. Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer. Free Radic Biol Med. 2018 Dec;129:454-462.
溶解性: DMSO  :  100  mg/mL  (226.82  mM;  Need  ultrasonic)
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 0 ml 0 ml 0 ml
5 mM 0 ml 0 ml 0 ml
10 mM 0 ml 0 ml 0 ml
50 mM 0 ml 0 ml 0 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

质检证书(COA)

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摩尔浓度计算器

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