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• 产品描述： TRx 0237 (LMTX) mesylate is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.

• 靶点： Tau aggregation;BetaAmyloid; MicrotubuleAssociated

• 体外研究：
  TRx 0237 (LMTX™) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. It is a purified forms of Methylene Blue, an old drug that predates the FDA and is being widely used in Africa for the treatment for malaria as well as for methemoglobinemia and other conditions[2]. An in vitro study showed the ability of TRx 0237 in disrupting PHFs(paired helical filaments) isolated from Alzheimer's Disease brain tissues at the concentration at 0.16 μM。

• 体内研究：
  TRx 0237 dose-dependently rescues the learning impairment and restores behavioral flexibility in a spatial problem-solving water-maze task in L1 (minimum effective dose: 9 mg MT/kg for TRx0237) and correctes motor learning in L66 (effective doses: 4 mg MT/kg). It reduces the number of tau-reactive neurons, particularly in the hippocampus and entorhinal cortex in L1 and in a more widespread manner in L66。

• 参考文献：
  1. LMTM. THERAPEUTICS overview. 2. Panza F, et al. Tau aggregation inhibitors: the future of Alzheimer's pharmacotherapy?. Expert Opin Pharmacother. 2016, 17(4):457-61. 3. Gui W, Xu S, Dang Z, et al. In Vitro and in Vivo Effect of Mapk Signal Transduction Pathway Inhibitors on Echinococcus multilocularis[J]. Journal of Parasitology. 2019 Feb;105(1):146-154. 4. Liu Z, Wang F, Tang M, et al. Amyloid β and tau are involved in sleep disorder in Alzheimer's disease by orexin A and adenosine A (1) receptor[J]. International journal of molecular medicine. 2019 Jan;43(1):435-442.

• 溶解性： Soluble  in  DMSO、H2O

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.094 ml	10.469 ml	20.937 ml
  5 mM	0.419 ml	2.094 ml	4.187 ml
  10 mM	0.209 ml	1.047 ml	2.094 ml
  50 mM	0.042 ml	0.209 ml	0.419 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *