| 产品描述： | TRx 0237 (LMTX) mesylate is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. |
| 靶点： |
Tau aggregation;BetaAmyloid; MicrotubuleAssociated |
| 体外研究： |
TRx 0237 (LMTX™) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. It is a purified forms of Methylene Blue, an old drug that predates the FDA and is being widely used in Africa for the treatment for malaria as well as for methemoglobinemia and other conditions[2]. An in vitro study showed the ability of TRx 0237 in disrupting PHFs(paired helical filaments) isolated from Alzheimer's Disease brain tissues at the concentration at 0.16 μM。 |
| 体内研究： |
TRx 0237 dose-dependently rescues the learning impairment and restores behavioral flexibility in a spatial problem-solving water-maze task in L1 (minimum effective dose: 9 mg MT/kg for TRx0237) and correctes motor learning in L66 (effective doses: 4 mg MT/kg). It reduces the number of tau-reactive neurons, particularly in the hippocampus and entorhinal cortex in L1 and in a more widespread manner in L66。 |
| 参考文献： |
1. LMTM. THERAPEUTICS overview. 2. Panza F, et al. Tau aggregation inhibitors: the future of Alzheimer's pharmacotherapy?. Expert Opin Pharmacother. 2016, 17(4):457-61. 3. Gui W, Xu S, Dang Z, et al. In Vitro and in Vivo Effect of Mapk Signal Transduction Pathway Inhibitors on Echinococcus multilocularis[J]. Journal of Parasitology. 2019 Feb;105(1):146-154. 4. Liu Z, Wang F, Tang M, et al. Amyloid β and tau are involved in sleep disorder in Alzheimer's disease by orexin A and adenosine A (1) receptor[J]. International journal of molecular medicine. 2019 Jan;43(1):435-442. |
| 溶解性： |
Soluble in DMSO、H2O |
| 保存条件： |
-20℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.094 ml |
10.469 ml |
20.937 ml |
| 5 mM |
0.419 ml |
2.094 ml |
4.187 ml |
| 10 mM |
0.209 ml |
1.047 ml |
2.094 ml |
| 50 mM |
0.042 ml |
0.209 ml |
0.419 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京