| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
S81264-1mg |
≥99% | ￥150.00 | 货期：2-3天 | - | - | - |
|
S81264-2mg |
99.5% | ￥260.00 | 5 | - | - | - |
|
S81264-5mg |
99.5% | ￥380.00 | 1 | - | - | - |
|
S81264-10mg |
≥99% | ￥560.00 | 货期：2-3天 | - | - | - |
|
S81264-25mg |
≥99% | ￥610.00 | 货期：2-3天 | - | - | - |
|
S81264-50mg |
≥99% | ￥1100.00 | 货期：2-3天 | - | - | - |
|
S81264-100mg |
≥99% | ￥1780.00 | 货期：2-3天 | - | - | - |
|
Wnt-C59 (C59) is a highly potent and oral porcupine (PORCN) inhibitor with an IC50 of 74 pM.
| 产品描述： | Wnt-C59 (C59) is a highly potent and oral porcupine (PORCN) inhibitor with an IC50 of 74 pM. | ||||||||||||||||||||
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| 靶点： | IC50: 74 pM (PORCN);Wnt/beta-catenin; Porcupine | ||||||||||||||||||||
| 体内研究： | Wnt-C59 displays good bioavailability in mice. Wnt-C59 blocks progression of mammary tumors in MMTV-WNT1 transgenic mice while downregulating Wnt/β-catenin target genes. Wnt-C59 has the potential to eradicate cancer stem cells in human tumors. Wnt-C59 inhibits stemness properties of NPC cells in a dosage-dependent manner by arresting sphere formation in both HNE1 and SUNE1 cells | ||||||||||||||||||||
| 参考文献： | 1. Proffitt KD, et al. Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. Cancer Res. 2013 Jan 15;73(2):502-7. 2. Cheng Y, et al. Wnt-C59 arrests stemness and suppresses growth of nasopharyngeal carcinoma in mice by inhibiting the Wnt pathway in the tumor microenvironment. Oncotarget. 2015 Jun 10;6(16):14428-39. | ||||||||||||||||||||
| 溶解性： | DMSO : 50 mg/mL (131.77 mM; Need ultrasonic) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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