货号	规格	价格	上海	北京	武汉	南京
S81265-5mg	97.5%	￥680.00 S81265-5mg ￥680.00 现货	6 6	-	-	-
S81265-10mg	97.5%	￥1105.00 S81265-10mg ￥1105.00 现货	7 7	-	-	-
S81265-25mg	97.5%	￥2210.00 S81265-25mg ￥2210.00 现货	6 6	-	-	-
S81265-100mg	≥97%	￥5800.00 S81265-100mg ￥5800.00 2-3天	0 货期：2-3天	-	-	-

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产品介绍

MG149 (Tip60 HAT inhibitor) is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF (IC50= 47 uM); little potent for PCAF and p300 (IC50 >200 uM)

产品描述：

MG149 (Tip60 HAT inhibitor) is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF (IC50= 47 uM); little potent for PCAF and p300 (IC50 >200 uM)

靶点：

IC50: 74/47 μM (Tip60/MOF);Apoptosis; Others; EpigeneticReaderDomain; HistoneAcetyltransferase

体外研究：

MG 149 (Tip60 HAT inhibitor), at 200 μM, inhibited about 90% of Tip60 activity but had no inhibitory impact on p300 and PCAF. MG 149 was essentially competitive with Ac-CoA and noncompetitive with the histone substrate. HAT inhibition studies with MG 149 demonstrated that both compounds inhibited the HAT activity of the nuclear extracts of different regions significantly (p < 0.05).

参考文献：

1. Ghizzoni M, et al. 6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site. Eur J Med Chem. 2012 Jan;47(1):337-44.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.937 ml	14.686 ml	29.372 ml
5 mM	0.587 ml	2.937 ml	5.874 ml
10 mM	0.294 ml	1.469 ml	2.937 ml
50 mM	0.059 ml	0.294 ml	0.587 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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