LM10

    
98%

(E)-3-(2-(1H-TETRAZOL-5-YL)VINYL)-6-FLUORO-1H-INDOLE

源叶(MedMol)
S81285 一键复制产品信息
1316695-35-8
C11H8FN5
229.2131232
货号 规格 价格 上海 北京 武汉 南京 购买数量
S81285-5mg 98% ¥110.00 8 - - -
S81285-25mg 98% ¥430.00 9 - - -
S81285-100mg 98% ¥1300.00 7 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

LM10 is a potent inhibitor of tryptophan 2,3-dioxygenase (TDO). Tryptophan 2,3-dioxygenase (TDO) is an unrelated hepatic enzyme that also degrades tryptophan along the kynurenine pathway. LM10 has the potential for the research of cancer diseases

产品描述: LM10 is a potent inhibitor of tryptophan 2,3-dioxygenase (TDO). Tryptophan 2,3-dioxygenase (TDO) is an unrelated hepatic enzyme that also degrades tryptophan along the kynurenine pathway. LM10 has the potential for the research of cancer diseases
靶点: TDO;Others
体内研究: LM10 (160 mg/kg; p.o.) prevents the growth of TDO-expressing P815 tumor cells and promotes better rejection of control clone P815B cl1, which does not express TDO. LM10 displays a good TDO inhibition (Ki = 5.6 μM) with a competitive inhibition profile. LM10 does not inhibit IDO and has a high solubility and bioavailability without obvious signs of toxicity. The plasma concentration of LM10 after oral administration of 160 mg/kg/day is between 20 and 40 μg/mL (87-175 μM), a concentration about 40 times above the IC50 measured in the cellular assay performed with the physiological concentration of plasma tryptophan.
参考文献: 1. Pilotte L, et al. Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase. Proc Natl Acad Sci U S A. 2012;109(7):2497-2502.
溶解性: DMSO  :  50  mg/mL  (218.14  mM;  Need  ultrasonic)
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 4.363 ml 21.814 ml 43.628 ml
5 mM 0.873 ml 4.363 ml 8.726 ml
10 mM 0.436 ml 2.181 ml 4.363 ml
50 mM 0.087 ml 0.436 ml 0.873 ml
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参考文献

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摩尔浓度计算器

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