GSK343 99%

GSK343

源叶(MedMol)
S81294
1346704-33-3
C31H39N7O2
541.69
1-异丙基-N-[(6-甲基-2-氧代-4-丙基-1,2-二氢-3-吡啶基)甲基]-6-[2-(4-甲基-1-哌嗪基)-4-吡啶基]-1H-吲唑-4-甲酰胺;1-Isopropyl-N-[(6-methyl-2-oxo-4-propyl-1,2-dihydro-3-pyridinyl)m ethyl]-6-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]-1H-in
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶(MedMol) S81294-2mg 99% ¥238.00元 >10 - - -
源叶(MedMol) S81294-5mg 99% ¥314.50元 >10 - - -
源叶(MedMol) S81294-10mg 99% ¥595.00元 >10 - - -
源叶(MedMol) S81294-25mg 99% ¥1190.00元 >10 - - -
源叶(MedMol) S81294-50mg 99% ¥2150.00元 8 - - -
源叶(MedMol) S81294-100mg 99% ¥4000.00元 4 - - -
产品介绍 参考文献(1篇) 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

GSK343 is a highly potent and selective EZH2 inhibitor with an IC50 of 4 nM.
产品描述: GSK343 is a highly potent and selective EZH2 inhibitor with an IC50 of 4 nM.
靶点: IC50: 4 nM (EZH2), 240 nM (EZH1);HistoneMethyltransferase; Autophagy
体内研究: Compare with the controls, GSK343 (5 mg/kg)-treated mice exhibits significantly inhibited tumor growth. The average tumor volume and weight of the GSK343-treated cohort is remarkably reduced. As early as 20 days post-implantation, a significant reduction in tumor growth is observed in the GSK343-treated cohort relative to the control cohort; this difference persisted through the remainder of the study. In addition, compare with the control cohort, the GSK343-treated animals in the xenograft model show a remarkable increase in messenger RNA levels of E-cadherin but a significant decrease in vimentin messenger RNA levels
参考文献: 1. Sharad K, et al. Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2. ACS Med Chem Lett. 2012 Oct 19;3(12):1091-6. 2. Ding M, et al. The polycomb group protein enhancer of zeste 2 is a novel therapeutic target for cervical cancer. Clin Exp Pharmacol Physiol. 2015 May;42(5):458-64.
溶解性: DMSO  :  15.62  mg/mL  (28.84  mM;  Need  ultrasonic)    H2O  :  <  0.1  mg/mL  (ultrasonic;warming;heat  to  60°C)  (insoluble)
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 1.846 ml 9.23 ml 18.461 ml
5 mM 0.369 ml 1.846 ml 3.692 ml
10 mM 0.185 ml 0.923 ml 1.846 ml
50 mM 0.037 ml 0.185 ml 0.369 ml
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摩尔浓度计算器

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