货号	规格	价格	上海	北京	武汉	南京
S81328-2mg	≥99%	￥510.00 S81328-2mg ￥510.00 现货	10 10	-	-	-
S81328-5mg	≥99%	￥1030.00 S81328-5mg ￥1030.00 现货	10 10	-	-	-
S81328-10mg	≥99%	￥1750.00 S81328-10mg ￥1750.00 现货	10 10	-	-	-
S81328-25mg	≥99%	￥3500.00 S81328-25mg ￥3500.00 现货	8 8	-	-	-
S81328-50mg	≥99%	￥5664.00 S81328-50mg ￥5664.00 现货	6 6	-	-	-
S81328-100mg	≥99%	￥8960.00 S81328-100mg ￥8960.00 现货	6 6	-	-	-

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产品介绍

VLX1570 is a competitive inhibitor of proteasome deubiquitinases (DUBs) with an IC50 of approximate 10 μM.

产品描述：

VLX1570 is a competitive inhibitor of proteasome deubiquitinases (DUBs) with an IC50 of approximate 10 μM.

靶点：

IC50: appr 10 μM (Deubiquitinase);DUB

体内研究：

VLX1570 (3 mg/kg) significantly decreases tumor growth in mice bearing KMS-11 multiple myeloma cells. VLX1570 (4.4 mg/kg, i.p.) markedly suppresses tumor growth, without obvious weight loss and other signs of systemic toxicity in the Waldenstrom macroglobulinemia (WM)-bearing mice

参考文献：

1. Wang X, et al. Synthesis and evaluation of derivatives of the proteasome deubiquitinase inhibitor b-AP15. Chem Biol Drug Des. 2015 Nov;86(5):1036-48. 2. Wang X, et al. The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells. Sci Rep. 2016 Jun 6;6:26979. 3. Paulus A, et al. Coinhibition of the deubiquitinating enzymes, USP14 and UCHL5, with VLX1570 is lethal to ibrutinib- or bortezomib-resistant Waldenstrom macroglobulinemia tumor cells. Blood Cancer J. 2016 Nov 4;6(11):e492.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.13 ml	10.652 ml	21.304 ml
5 mM	0.426 ml	2.13 ml	4.261 ml
10 mM	0.213 ml	1.065 ml	2.13 ml
50 mM	0.043 ml	0.213 ml	0.426 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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