产品描述: | Sevelamer hydrochloride is an orally active and phosphate binding agent used for research of hyperphosphatemia with chronic kidney disease. Sevelamer hydrochloride consists of polyallylamine that is crosslinked with epichlorohydrin |
靶点: |
FXR;Autophagy;FXR; Autophagy |
体内研究: |
Sevelamer hydrochloride (1% mixed in diet; p.o.; once daily for 5 weeks) reduces Npt2b-deficient mice serum phosphate levels, but fails to reduce the level in uremic WT mice.Sevelamer hydrochloride leads to a significant decrease in osteoclast number in uremic WT mice with a trend toward further decrease in Npt2b-/- mice.Sevelamer hydrochloride leads to a significant increase in Npt2b protein expression |
参考文献: |
1. Sevelamer, From Wikipedia 2. Bennis Y, et al. The Effect of Sevelamer on Serum Levels of Gut-Derived Uremic Toxins: Results from In Vitro Experiments and A Multicenter, Double-Blind, Placebo-Controlled, Randomized Clinical Trial. Toxins (Basel). 2019 May 17;11(5):279. 3. Susan C Schiavi, et al. Npt2b deletion attenuates hyperphosphatemia associated with CKD. J Am Soc Nephrol. 2012 Oct;23(10):1691-700. |
保存条件: |
2-8℃ |
配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
1 mM |
6.684 ml |
33.418 ml |
66.836 ml |
5 mM |
1.337 ml |
6.684 ml |
13.367 ml |
10 mM |
0.668 ml |
3.342 ml |
6.684 ml |
50 mM |
0.134 ml |
0.668 ml |
1.337 ml |
|
注意: |
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