SB 239063 99%

SB 239063

MedMol
S81421
193551-21-2
C20H21FN4O2
368.4
trans-1-(4-Hydroxycyclohexyl)-4-(4-fluorophenyl)-5-(2-methoxypyridimidin-4-yl)imidazole; Kinome_3168; Tocris-1962;
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
MedMol S81421-5mg 99% ¥405.00元 8 - - -
源叶(MedMol) S81421-10mg 99% ¥630.00元 预计交期:2-3天 - - -
源叶(MedMol) S81421-50mg 99% ¥2000.00元 预计交期:2-3天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

SB 239063 is a potent, selective and orally active p38 MAPK inhibitor, exhibits an IC50 of 44 nM for recombinant purified human p38α, with equipotent inhibitory activity against p38α and p38β. SB 239063 has no effect on p38γ or p38δ. With anti-asthma activity and also be used to enhance memory which is impaired due to aging or medical conditions, such as, AD
产品描述: SB 239063 is a potent, selective and orally active p38 MAPK inhibitor, exhibits an IC50 of 44 nM for recombinant purified human p38α, with equipotent inhibitory activity against p38α and p38β. SB 239063 has no effect on p38γ or p38δ. With anti-asthma activity and also be used to enhance memory which is impaired due to aging or medical conditions, such as, AD
靶点: IC50: 44 nM (Human p38α);p38MAPK; Autophagy
体内研究: SB 239063 (12 mg/kg; p.o.; 1 hour before and 4 hours after OA challenge; b.i.d. for 3 days) significantly inhibits the resultant antigen-induced airway eosinophilia. SB 239063 (12 mg/kg; p.o.) almost abolishes ovalbumin (OA)-induced airway eosinophilia (~ 93% inhibition) by inhalation. SB 239063 is a potent inhibitor of LPS-induced TNF-alpha production in the mouse peritoneal cavity with an EC50 of 5.8 mg/kg (2.8–10.3; 95% CL)
参考文献: 1. Underwood DC, et al. SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence. J Pharmacol Exp Ther. 2000 Apr;293(1):281-8. 2. Matthew Huentelman, et al. Methods of treating memory loss and enhancing memory performance. US 20120245188 A1.
溶解性: DMSO  :  33.33  mg/mL  (90.47  mM;  Need  ultrasonic)
保存条件: 2-8℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.714 ml 13.572 ml 27.144 ml
5 mM 0.543 ml 2.714 ml 5.429 ml
10 mM 0.271 ml 1.357 ml 2.714 ml
50 mM 0.054 ml 0.271 ml 0.543 ml
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参考文献

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