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S81436

Ixabepilone

源叶(MedMol) 95%
  • 英文名:
  • Ixabepilone
  • 别名:
  • 伊沙匹隆;Ixempra; [1S-[1R*,3R*(E),7R*,10S*,11R*,12R*,16S*]]-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4-aza-17-oxabicyclo[14.1.0]heptadecane-5,9-dione; 16-aza-ep
  • CAS号:
  • 219989-84-1
  • 分子式:
  • C2H42N2O5S
  • 分子量:
  • 506.7
  • 核磁/质谱:
品牌货号产品规格价格(RMB) 库存(上海) 北京 武汉 南京 数量计量单位 加入购物车...
源叶(MedMol) S81436-1mg 95% ¥326.40元 6 - - - EA 加入购物车
源叶(MedMol) S81436-2mg 95% ¥544.00元 5 - - - EA 加入购物车
源叶(MedMol) S81436-5mg 95% ¥1020.00元 4 - - - EA 加入购物车
源叶(MedMol) S81436-10mg 95% ¥1496.00元 5 - - - EA 加入购物车
源叶(MedMol) S81436-25mg 95% ¥3060.00元 预计交期:2-3天 - - - EA 加入购物车
源叶(MedMol) S81436-50mg 95% ¥4800.00元 预计交期:2-3天 - - - EA 加入购物车
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参考文献

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  • 提示:详情请下载说明书。
  • 产品描述: Ixabepilone (BMS-247550) is an orally bioavailable microtubule inhibitor, which binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arrests cells in the G2-M phase of the cell cycle and induces tumor cell apoptosis.
  • 靶点: Apoptosis;Microtubule Associated;Apoptosis; MicrotubuleAssociated
  • 体内研究:
    In vivo, BMS-247550 has clearly demonstrated antitumor activity that is superior to paclitaxel in both paclitaxel-resistant and -sensitive tumors. BMS-247550 is more efficacious compared to paclitaxel in all five paclitaxel-resistant tumors evaluated in this study (four human and one murine): i.e., the clinically derived paclitaxel resistant Pat-7 ovarian carcinoma, the A2780Tax ovarian carcinoma that is resistant to paclitaxel because of tubulin mutations, the HCT116/VM46 MDR colon carcinoma, the clinically derived paclitaxel-resistant Pat-21 breast carcinoma, and the murine fibrosarcoma M5076. Against three paclitaxel-sensitive human tumor xenografts, BMS-247550 produces antitumor activity equivalent to paclitaxel: i.e., A2780 human ovarian carcinoma, HCT116, and LS174T human colon carcinoma
  • 细胞实验: HCT116 cells from cultures are collected by trypsinization after 1, 2, 4, 8, 16, and 24 h exposure to 7.5 nm of BMS-247550. Cells are pelleted and fixed in 80% ethanol at −20°C. After an overnight storage at −20°C, cells are rehydrated with PBS buffer and DNA stain by incubation with propidium iodide (5 μg/ml) in 0.1% RNase for 15–30 min. Fluorescence-activated cell sorter acquisition is performed using the FACS Calibur instrument and analysis is done using Cellquest and Modfit software. (Only for Reference)
  • 参考文献:
    1.Lee FY, et al. Clin Cancer Res. 2001, 7(5):1429-1437.
  • 溶解性: Ethanol:93  mg/mL  (183.5  mM)    DMSO:93  mg/mL  (183.5  mM)    H2O:<1  mg/mL
  • 保存条件: -20℃
  • 配置溶液浓度参考:
    1mg 5mg 10mg
    1 mM 1.974 ml 9.868 ml 19.736 ml
    5 mM 0.395 ml 1.974 ml 3.947 ml
    10 mM 0.197 ml 0.987 ml 1.974 ml
    50 mM 0.039 ml 0.197 ml 0.395 ml
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