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• 产品描述： Ferrostatin-1 (Fer-1), a potent and selective ferroptosis inhibitor, suppresses Erastin-induced ferroptosis in HT-1080 cells (EC50=60 nM). Ferrostatin-1, a synthetic antioxidant, acts via a reductive mechanism to prevent damage to membrane lipids and thereby inhibits cell death. Antifungal Activity

• 靶点： EC50: 60 nM (Ferroptosis);Ferroptosis; Antifungal

• 体内研究：
  Ferrostatin-1 inhibits cell death in cellular models of Huntington's disease (HD), periventricular leukomalacia (PVL), and kidney dysfunction. Ferrostatin-1 (0.8 mg/kg; tail vein injection) effectively alleviates LPS-induced induced acute lung injury (ALI). Ferrostatin-1 (i.p.; 5 mg/kg; C57BL/6J mice) improves renal function in mice with rhabdomyolysis

• 参考文献：
  1. Dixon SJ, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149(5):1060-1072. 2. Skouta R, Dixon SJ, Wang J, et al. Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models. J Am Chem Soc. 2014;136(12):4551-4556. 3. Horwath MC, et al. Antifungal Activity of the Lipophilic Antioxidant Ferrostatin-1. Chembiochem. 2017;18(20):2069-2078. 4. Liu P, Feng Y, et al. Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis. Cell Mol Biol Lett. 2020;25:10. Published 2020 Feb 27. 5. Melania Guerrero Hue, et al. FP282 FERROPTOSIS-MEDIATED CELL DEATH IS DECREASED BY CURCUMIN IN RENAL DAMAGE ASSOCIATED TO RHABDOMYOLYSIS, Nephrology Dialysis Transplantation, Volume 34, Issue Supplement_1, June 2019, gfz106.FP282.

• 溶解性： DMSO  :  125  mg/mL  (476.46  mM;  Need  ultrasonic)

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	3.812 ml	19.059 ml	38.117 ml
  5 mM	0.762 ml	3.812 ml	7.623 ml
  10 mM	0.381 ml	1.906 ml	3.812 ml
  50 mM	0.076 ml	0.381 ml	0.762 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

• 20. [4] Yinhao ZHANG et al."Rehmanniae Radix Praeparata aqueous extract improves hepatic ischemia/reperfusion injury by restoring intracellular iron homeostasis."Chinese Journal of Natural Medicines.2024 Sep;22:769

• 19. [3.1] Jing Xin et al."Melatonin mitigates the lipopolysaccharide-induced myocardial injury in rats by blocking the p53/xCT pathway-mediated ferroptosis."NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY.2024 Aug;:1-11

• 18. [5.3] Xue Xiaoyong et al."Si-Wu-Tang alleviates metabolic dysfunction-associated fatty liver disease by inhibiting ACSL4-mediated arachidonic acid metabolism and ferroptosis in MCD diet-fed mice."Chinese Medicine.2024 Dec;19(1):1-22

• 17. [IF=4] Yong-Zhuo Li et al."Naringenin enhances the efficacy of ferroptosis inducers by attenuating aerobic glycolysis by activating the AMPK-PGC1α signalling axis in liver cancer."Heliyon".2024 Jun;10:

• 16. [IF=13.6] Lin Zhang et al."Protective effects and mechanism of chemical- and plant-based selenocystine against cadmium-induced liver damage."JOURNAL OF HAZARDOUS MATERIALS".2024 Apr;468:133812

• 15. [IF=6.2] Hangping Chen et al."Butyrate ameliorated ferroptosis in ulcerative colitis through modulating Nrf2/GPX4 signal pathway and improving intestinal barrier."BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE.2024 Feb;1870:166984

• 14. [IF=9] Zhu Haixia et al."Gss deficiency causes age-related fertility impairment via ROS-triggered ferroptosis in the testes of mice."Cell Death & Disease.2023 Dec;14(12):1-14

• 13. [IF=3.8] Zhang Yunwen et al."Knockdown of SLC39A14 inhibits glioma progression by promoting erastin-induced ferroptosis SLC39A14 knockdown inhibits glioma progression."BMC CANCER.2023 Dec;23(1):1-15

• 12. [IF=4.5] Feng Lian et al."Ubiquitin-specific peptidase 10 attenuates the ferroptosis to promote thyroid cancer malignancy by facilitating GPX4 via elevating SIRT6."ENVIRONMENTAL TOXICOLOGY.2023 Oct;:

• 11. [IF=3.3] Zhang Xueyan et al."A (Traditional Chinese Medicine) TCM-Inspired Doxorubicin Resistance Reversing Strategy: Preparation, Characterization, and Application of a Co-loaded pH-Sensitive Liposome."AAPS PHARMSCITECH.10.1208/s12249-023-02630-8

• 10. [IF=4.6] Minghui Liu et al."Benzophenanthridine Alkaloid Chelerythrine Elicits Necroptosis of Gastric Cancer Cells via Selective Conjugation at the Redox Hyperreactive C-Terminal Sec498 Residue of Cytosolic Selenoprotein Thioredoxin Reductase."MOLECULES.10.3390/mol

• 9. [IF=6.706] Peiwen Zhang et al."n-3 PUFA Promotes Ferroptosis in PCOS GCs by Inhibiting YAP1 through Activation of the Hippo Pathway."Nutrients.2023 Jan;15(8):1927

• 8. [6.51] Yang Wang et al."Local Delivery of Artesunate Dimer Liposomes Incorporated Injectable Hydrogel for H2O2 and pH-Independent Chemodynamic Therapy."INTERNATIONAL JOURNAL OF PHARMACEUTICS.2023 Mar;:122822

• 7. [17.694] Fang Fang et al."Continuous Spatiotemporal Therapy of A Full-API Nanodrug via Multi-Step Tandem Endogenous Biosynthesis."Nature Communications.2023 Mar;14(1):1-14

• 6. [2.893] Yingxi Wang et al."Relationship Between ACSL4-Mediated Ferroptosis and Chronic Obstructive Pulmonary Disease."International Journal of Chronic Obstructive Pulmonary Disease.

• 5. [4.831] Ying Lan et al."Polysiloxane-based hyperbranched fluorescent probe for dynamic visualization of HClO in lysosomes and vivo."SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY.2023 Jun;294:122527

• 4. [IF=6.313] Yijia Yang et al."Piperlongumine Inhibits Thioredoxin Reductase 1 by Targeting Selenocysteine Residues and Sensitizes Cancer Cells to Erastin."Antioxidants-Basel. 2022 Apr;11(4):710

• 3. [IF=3.59] Jie Zhao et al."Activation of SSAT1/ALOX15 Axis Aggravates Cerebral Ischemia/Reperfusion Injury via Triggering Neuronal Ferroptosis."Neuroscience. 2022 Mar;485:78

• 2. [IF=8.183] Zhicheng Zhang et al."Versatile iron-vitamin K 3 derivative-based nanoscale coordination polymer augments tumor ferroptotic therapy."Nano Res. 2021 Jul;14(7):2398-2409

• 1. [IF=11.556] Junjie Ren et al."Ultrasound (US)-activated redox dyshomeostasis therapy reinforced by immunogenic cell death (ICD) through a mitochondrial targeting liposomal nanosystem."Theranostics. 2021; 11(19): 9470–9491

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *