货号	规格	价格	上海	北京	武汉	南京	购买数量
S81484-100mg	99%	￥120.00 S81484-100mg ￥120.00 现货	241 >10	-	-	-
S81484-500mg	99%	￥300.00 S81484-500mg ￥300.00 现货	53 >10	-	-	-

产品介绍

Mefloquine hydrochloride (Mefloquin hydrochloride), a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor. Mefloquine hydrochloride is also a K+ channel (KvQT1/minK) antagonist with an IC50 of ~1 μM. Mefloquine hydrochloride can be used for malaria, systemic lupus erythematosus and cancer research

产品描述：

靶点：

Plasmodium;Others

体内研究：

Mefloquine hydrochloride (5 mg/kg; i.p.; daily; 14 days) reverses the lower vertebral cancellous bone volume and bone formation; and has modest effects on cortical bone volume, thickness, and moment of inertia in old mice

参考文献：

1. Kang J, et al. Interactions of the antimalarial drug mefloquine with the human cardiac potassium channels KvLQT1/minK andHERG. J Pharmacol Exp Ther. 2001 Oct;299(1):290-6. 2. Yan KH, et al. Mefloquine exerts anticancer activity in prostate cancer cells via ROS-mediated modulation of Akt, ERK, JNK and AMPK signaling. Oncol Lett. 2013 May;5(5):1541-1545. 3. Kaho Shionoya, et al. Mefloquine, a Potent Anti-severe Acute Respiratory Syndrome-Related Coronavirus 2 (SARS-CoV-2) Drug as an Entry Inhibitor in vitro. Front Microbiol. 2021 Apr 30;12:651403. 4. Rafael Pacheco-Costa, et al. Reversal of loss of bone mass in old mice treated with mefloquine. Bone. 2018 Sep;114:22-31.

溶解性：

DMSO : 50 mg/mL (120.55 mM; Need ultrasonic) H2O : 2.86 mg/mL (6.90 mM; ultrasonic and warming and heat to 60°C)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.411 ml	12.055 ml	24.11 ml
5 mM	0.482 ml	2.411 ml	4.822 ml
10 mM	0.241 ml	1.205 ml	2.411 ml
50 mM	0.048 ml	0.241 ml	0.482 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

Mefloquine