Losmapimod 97%

Losmapimod

源叶(MedMol)
S81495
585543-15-3
C22H26FN3O2
383.46
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶(MedMol) S81495-2mg 97% ¥180.00元 10 - - -
源叶(MedMol) S81495-5mg 97% ¥245.00元 6 - - -
源叶(MedMol) S81495-10mg 97% ¥440.00元 7 - - -
源叶(MedMol) S81495-25mg 97% ¥840.00元 7 - - -
源叶(MedMol) S81495-50mg 97% ¥1400.00元 4 - - -
源叶(MedMol) S81495-100mg 97% ¥1900.00元 预计交期:2-3天 - - -
源叶(MedMol) S81495-200mg 97% ¥3500.00元 预计交期:2-3天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

Losmapimod (GSK-AHAB) is a selective, potent, and orally active p38 MAPK inhibitor with pKis of 8.1 and 7.6 for p38α and p38β, respectively
产品描述: Losmapimod (GSK-AHAB) is a selective, potent, and orally active p38 MAPK inhibitor with pKis of 8.1 and 7.6 for p38α and p38β, respectively
靶点: pKi: 8.1 (p38α), 7.6 (p38β);p38MAPK; Autophagy
体内研究: In the spontaneously hypertensive stroke-prone rat (SHR-SP), chronic treatment with GSK-AHAB significantly and dose-dependently improves survival, endothelial-dependent and -independent vascular relaxation, and indices of renal function, and it attenuates dyslipidemia, hypertension, cardiac remodeling, plasma renin activity (PRA), aldosterone, and interleukin-1β (IL-1β)
参考文献: 1. Willette RN, et al. Differential effects of p38 mitogen-activated protein kinase and cyclooxygenase 2 inhibitors in a model of cardiovascular disease. J Pharmacol Exp Ther. 2009 Sep;330(3):964-70. 2. Zhang XM, et al. Suppression of mitochondrial fission in experimental cerebral ischemia: The potential neuroprotective target of p38 MAPK inhibition. Neurochem Int. 2015 Nov;90:1-8.
溶解性: Ethanol  :  33.33  mg/mL  (86.92  mM;  Need  ultrasonic)    DMSO  :  27.5  mg/mL  (71.72  mM;  Need  ultrasonic)
保存条件: 2-8℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.608 ml 13.039 ml 26.078 ml
5 mM 0.522 ml 2.608 ml 5.216 ml
10 mM 0.261 ml 1.304 ml 2.608 ml
50 mM 0.052 ml 0.261 ml 0.522 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

质检证书(COA)

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摩尔浓度计算器

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