PH-797804 98%

PH-797804

源叶(MedMol)
S81496
586379-66-0
C22H19BrF2N2O3
477.3
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶(MedMol) S81496-5mg 98% ¥740.00元 9 - - -
源叶(MedMol) S81496-10mg 98% ¥1105.00元 8 - - -
源叶(MedMol) S81496-25mg 98% ¥2465.00元 7 - - -
源叶(MedMol) S81496-100mg 98% ¥6100.00元 7 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

PH-797804 is a ATP-competitive, selective p38α/p38β inhibitor (IC50=26 nM and Ki=5.8 nM for p38α; Ki=40 nM for p38β) and does not inhibit JNK2.
产品描述: PH-797804 is a ATP-competitive, selective p38α/p38β inhibitor (IC50=26 nM and Ki=5.8 nM for p38α; Ki=40 nM for p38β) and does not inhibit JNK2.
靶点: IC50: 26 nM (p38α) Ki: 5.8 nM (p38α), 40 nM (p38β);p38MAPK; Autophagy
体内研究: Orally dosing of PH-797804 effectively inhibits acute inflammatory responses induced by systemically administered endotoxin in both rat and cynomolgus monkeys. PH-797804 treatment for 10 days demonstrates robust anti-inflammatory activity in chronic disease models, significantly reducing both joint inflammation and associated bone loss in streptococcal cell wall-induced arthritis in rats and mouse collagen-induced arthritis. Dose-response analysis resulted in ED50 values of 0.07 mg/kg and 0.095 mg/kg in rat and cynomolgus monkeys, respectively. PH-797804 inhibits LPS-induced TNF-α, IL-6, and MK-2 activity in a dose- and concentration-dependent manner in a human endotoxin challenge model
参考文献: 1. Hope HR, et al. Anti-inflammatory properties of a novel N-phenyl pyridinone inhibitor of p38 mitogen-activated protein kinase: preclinical-to-clinical translation. J Pharmacol Exp Ther, 2009, 331(3), 882-895. 2. Xing L, et al. Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804. Biochemistry, 2009, 48(27), 6402-6411.
溶解性: DMSO  :  50  mg/mL  (104.76  mM;  Need  ultrasonic)
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.095 ml 10.476 ml 20.951 ml
5 mM 0.419 ml 2.095 ml 4.19 ml
10 mM 0.21 ml 1.048 ml 2.095 ml
50 mM 0.042 ml 0.21 ml 0.419 ml
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参考文献

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摩尔浓度计算器

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