| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
S81497-2mg |
99.9% | ￥272.00 | 5 | - | - | - |
|
S81497-5mg |
99.9% | ￥340.00 | 6 | - | - | - |
|
S81497-10mg |
99.9% | ￥586.50 | 4 | - | - | - |
|
S81497-25mg |
99.9% | ￥1122.00 | 6 | - | - | - |
|
S81497-50mg |
99.9% | ￥1955.00 | 5 | - | - | - |
|
S81497-100mg |
≥95% | ￥2975.00 | 货期：2-3天 | - | - | - |
|
S81497-200mg |
≥95% | ￥5525.00 | 货期：2-3天 | - | - | - |
|
ZCL278 is a selective Cdc42 modulator that directly binds to Cdc42 and inhibits its functions with Kd of 11.4 μM for Cdc42-ZCL278 affinity in surface plasmon resonance (SPR) experiment.
| 产品描述： | ZCL278 is a selective Cdc42 modulator that directly binds to Cdc42 and inhibits its functions with Kd of 11.4 μM for Cdc42-ZCL278 affinity in surface plasmon resonance (SPR) experiment. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | Kd: 11.4 μM (Cdc42);CDK; Ras | ||||||||||||||||||||
| 体内研究： | ZCL278 reduces the JUNV RNA load in the spleen more than 33-fold, with JUNV RNA being undetectable in 5 out of 8 mice. These results are similar to those seen in Gabapentin-treated mice, demonstrating that ZCL278 can abrogate JUNV replication | ||||||||||||||||||||
| 参考文献： | 1. Friesland A, et al. Small molecule targeting Cdc42-intersectin interaction disrupts Golgi organization and suppresses cell motility. Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1261-6. 2. Chou YY, et al. Identification and Characterization of a Novel Broad-Spectrum Virus Entry Inhibitor. J Virol. 2016 Apr 14;90(9):4494-510. | ||||||||||||||||||||
| 溶解性： | DMSO : 50 mg/mL (85.49 mM; Need ultrasonic) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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