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S81532

2-Ethyl-2-Methylsuccinimide

源叶(MedMol) 99%
  • 英文名:
  • 2-Ethyl-2-Methylsuccinimide
  • 别名:
  • 乙琥胺
  • CAS号:
  • 77-67-8
  • 分子式:
  • C7H11NO2
  • 分子量:
  • 141.17
  • MDL:
  • MFCD00072123
品牌货号产品规格价格(RMB) 库存(上海) 北京 武汉 南京 数量计量单位 加入购物车...
源叶(MedMol) S81532-500mg 99% ¥160.00元 6 - - - EA 加入购物车
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  • 提示:详情请下载说明书。
  • 产品描述: Ethosuximide is an anticonvulsant, blocks the low voltage-activated T-type calcium channel used in the treatment of absence seizures unaccompanied by other types of seizures.
  • 靶点: calcium channel
  • 体内研究:
    Anti-epileptic drug ethosuximide rescues the short lifespan and chemosensory defects exhibited by C. elegans null mutants of dnj-14, the worm orthologue of the DNAJC5 gene mutated in autosomal-dominant adult-onset neuronal ceroid lipofuscinosis. It also ameliorates the locomotion impairment and short lifespan of worms expressing a human Tau mutant that causes frontotemporal dementia. Ethosuximide extends lifespan by inhibiting the function of specific chemosensory neurons. It increases neurogenesis, reduces neurodegeneration, and reverses cognitive impairments in rat model of AD like phenotypes
  • 细胞实验: Mouse Neuro2A (N2A) neuroblastoma cells are cultured on 6-well plates and treated with retinoic acid to induce neuronal differentiation. After 24 h, N2A cells are treated with vehicle control (PBS) or increasing concentrations of ethosuximide for 5 h. Total RNA is then isolated, DNase-treated and reverse transcribed to cDNA. qRT-PCR is run above normalising to the reference genes glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and β-actin (ACTB). (Only for Reference)
  • 参考文献:
    1.Coulter DA, et al. Ann Neurol. 1989, 25(6):582-93. 2.Tiwari SK, et al. J Biol Chem. 2015, 290(47):28540-28558. 3.Collins JJ, et al. PLoS Genet. 2008, 4(10):e120200230. 4.Chen X, et al. Mol Neurodegener. 2015, 10:51.
  • 溶解性: H2O:198.3  mM    DMSO:198.3  mM
  • 保存条件: 2-8℃
  • 配置溶液浓度参考:
    1mg 5mg 10mg
    1 mM 7.084 ml 35.418 ml 70.837 ml
    5 mM 1.417 ml 7.084 ml 14.167 ml
    10 mM 0.708 ml 3.542 ml 7.084 ml
    50 mM 0.142 ml 0.708 ml 1.417 ml
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