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• 产品描述： Ethosuximide is an anticonvulsant, blocks the low voltage-activated T-type calcium channel used in the treatment of absence seizures unaccompanied by other types of seizures.

• 靶点： calcium channel

• 体内研究：
  Anti-epileptic drug ethosuximide rescues the short lifespan and chemosensory defects exhibited by C. elegans null mutants of dnj-14, the worm orthologue of the DNAJC5 gene mutated in autosomal-dominant adult-onset neuronal ceroid lipofuscinosis. It also ameliorates the locomotion impairment and short lifespan of worms expressing a human Tau mutant that causes frontotemporal dementia. Ethosuximide extends lifespan by inhibiting the function of specific chemosensory neurons. It increases neurogenesis, reduces neurodegeneration, and reverses cognitive impairments in rat model of AD like phenotypes

• 细胞实验： Mouse Neuro2A (N2A) neuroblastoma cells are cultured on 6-well plates and treated with retinoic acid to induce neuronal differentiation. After 24 h, N2A cells are treated with vehicle control (PBS) or increasing concentrations of ethosuximide for 5 h. Total RNA is then isolated, DNase-treated and reverse transcribed to cDNA. qRT-PCR is run above normalising to the reference genes glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and β-actin (ACTB). (Only for Reference)

• 参考文献：
  1.Coulter DA, et al. Ann Neurol. 1989, 25(6):582-93. 2.Tiwari SK, et al. J Biol Chem. 2015, 290(47):28540-28558. 3.Collins JJ, et al. PLoS Genet. 2008, 4(10):e120200230. 4.Chen X, et al. Mol Neurodegener. 2015, 10:51.

• 溶解性： H2O:198.3  mM    DMSO:198.3  mM

• 保存条件： 2-8℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	7.084 ml	35.418 ml	70.837 ml
  5 mM	1.417 ml	7.084 ml	14.167 ml
  10 mM	0.708 ml	3.542 ml	7.084 ml
  50 mM	0.142 ml	0.708 ml	1.417 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *