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S81623

Tirasemtiv

MedMol 99%
  • 英文名:
  • Tirasemtiv
  • 别名:
  • CK-2017357
  • CAS号:
  • 1005491-05-3
  • 分子式:
  • C12H14N4O
  • 分子量:
  • 230.2658
  • 核磁/质谱:
品牌货号产品规格价格(RMB) 库存(上海) 北京 武汉 南京 数量计量单位 加入购物车...
MedMol S81623-5mg 99% ¥612.00元 6 - - - EA 加入购物车
MedMol S81623-10mg 99% ¥952.00元 7 - - - EA 加入购物车
MedMol S81623-25mg 99% ¥1904.00元 8 - - - EA 加入购物车
MedMol S81623-100mg 99% ¥4500.00元 2 - - - EA 加入购物车
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参考文献

质检证书(COA)

摩尔浓度计算器

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  • 产品描述: Tirasemtiv is an activator of the fast skeletal muscle troponin complex.
  • 靶点: Troponin;Others
  • 体外研究:
    irasemtiv is a fast skeletal troponin activator that sensitizes the sarcomere to calcium; this mechanism of action amplifies the response of muscle to neuromuscular input producing greater force when nerve input is reduced. Tirasemtiv selectively sensitizes fast skeletal muscle troponin to calcium (Ca2+), and slows the rate of Ca2+ release from the regulatory troponin complex of fast skeletal muscle.
  • 体内研究:
    A single dose of Tirasemtiv significantly increases submaximal isometric force, forelimb grip strength, grid hang time, and rotarod performance in a female transgenic mouse model (B6SJL-SOD1G93A) of ALS with functional deficits. Additionally, diaphragm force and tidal volume are significantly higher in Tirasemtiv-treated female B6SJL-SOD1G93A mice. At the 25% deficit milestone, vehicle-treated B6SJL-SOD1G93A mice demonstrated forelimb grip strength of 49.6±4.6 g. Tirasemtiv increases grip strength by 38% to 68.6±8.1g (p<0.05, single tailed t-test). Tirasemtiv doses of 2, 2, 2, and 4 mg/kg given at approximately 20 min intervals to achieve a cumulative dose of 10 mg/kg. Regression analysis of the log dose vs. response relationship indicated that Tirasemtiv significantly increased muscle force in WT and mid-stage B6SJL-SOD1G93A mice (WT p<0.0001; mid-stage p=0.0028). At later stages of disease, the mice exhibited a trend for increased muscle function in response to Tirasemtivcompared to baseline (p=0.064)。
  • 参考文献:
    1. Hwee DT, et al. Fast skeletal muscle troponin activator tirasemtiv increases muscle function and performance in the B6SJL-SOD1G93A ALS mouse model. PLoS One. 2014 May 7;9(5):e96921.
  • 溶解性: soluble  in  DMSO
  • 保存条件: -20℃
  • 配置溶液浓度参考:
    1mg 5mg 10mg
    1 mM 4.343 ml 21.714 ml 43.428 ml
    5 mM 0.869 ml 4.343 ml 8.686 ml
    10 mM 0.434 ml 2.171 ml 4.343 ml
    50 mM 0.087 ml 0.434 ml 0.869 ml
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质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)


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