| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
S81753-1mg |
99.9% | ￥190.00 | 5 | - | - | - |
|
S81753-2mg |
99.9% | ￥245.00 | 5 | - | - | - |
|
S81753-5mg |
99.9% | ￥290.00 | 5 | - | - | - |
|
S81753-10mg |
99.9% | ￥430.00 | 6 | - | - | - |
|
S81753-25mg |
99.9% | ￥650.00 | 6 | - | - | - |
|
S81753-50mg |
≥98% | ￥1100.00 | 货期：2-3天 | - | - | - |
|
GNE-477 is a potent and efficacious dual PI3K (IC50=4 nM)/mTOR(Ki=21 nM) inhibitor.
| 产品描述： | GNE-477 is a potent and efficacious dual PI3K (IC50=4 nM)/mTOR(Ki=21 nM) inhibitor. | ||||||||||||||||||||
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| 靶点： | PI3Kα:4 nM (IC50);mTOR:21 nM (Ki);PI3K; mTOR | ||||||||||||||||||||
| 体外研究： | GNE-477 (Compound 8) has improved potency in the MCF7.1 cell proliferation assay with an EC50 of 143 nM | ||||||||||||||||||||
| 体内研究： | GNE-477 also exhibits stasis in a PC3 tumor growth inhibition study. In an experiment evaluating the tumor growth inhibition of a PC3 tumor xenograft over 14 days, stasis is achieved at a 20 mg/kg QD dose and significant inhibition is observed with doses as low as 1 mg/kg QD. GNE-477 is generally well tolerated during this study as demonstrated by acceptable levels of weight loss comparable to that observed with the animals in the vehicle cohort | ||||||||||||||||||||
| 参考文献： | 1. Heffron TP, et al. Identification of GNE-477, a potent and efficacious dual PI3K/mTOR inhibitor. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2408-11. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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