| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
S81772-1mg |
99.3% | ￥120.00 | 10 | - | - | - |
|
S81772-2mg |
99.3% | ￥180.00 | 10 | - | - | - |
|
S81772-5mg |
99.3% | ￥280.00 | 7 | - | - | - |
|
S81772-10mg |
99.3% | ￥450.00 | 6 | - | - | - |
|
S81772-25mg |
99.3% | ￥800.00 | 5 | - | - | - |
|
S81772-50mg |
≥99% | ￥1100.00 | 货期：2-3天 | - | - | - |
|
S81772-100mg |
≥99% | ￥1800.00 | 货期：2-3天 | - | - | - |
|
HPGDS inhibitor 1 is a potent, selective and orally active Hematopoietic Prostaglandin D Synthase (HPGDS) inhibitor with an IC50s of 0.6 nM and 32 nM in enzyme and cellular assays, respectively. HPGDS inhibitor 1 does not inhibit human L-PGDS, mPGES, COX-1, COX-2, or 5-LOX
| 产品描述： | HPGDS inhibitor 1 is a potent, selective and orally active Hematopoietic Prostaglandin D Synthase (HPGDS) inhibitor with an IC50s of 0.6 nM and 32 nM in enzyme and cellular assays, respectively. HPGDS inhibitor 1 does not inhibit human L-PGDS, mPGES, COX-1, COX-2, or 5-LOX | ||||||||||||||||||||
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| 靶点： | IC50: 0.6 nM (HPGDS in enzyme assays) and 32 nM (HPGDS in cellular assays);PGESynthase | ||||||||||||||||||||
| 体外研究： | HPGDS inhibitor 1 has equal potency against purified HPGDS from human, rat, dog, and sheep (IC50, 0.5-2.3 nM) | ||||||||||||||||||||
| 体内研究： | HPGDS inhibitor 1 (compound 8; 1 mg/kg) has excellent PK characteristics with 76% bioavailability, and the T1/2 is 4.1 hours in rats. Rats dosed orally with 1 mg/kg and 10 mg/kg HPGDS inhibitor 1 (compound 8) are sacrificed at various times. Oral administration of HPGDS inhibitor 1 blocks PGD2 production in the rat spleen; inhibition of PGD2 is inversely correlated with the plasma concentration of HPGDS inhibitor 1 in a time- and dose-dependent manner. HPGDS inhibitor 1 (compound 8; 1 mg/mL) illustrates efficacy in an in vivo sheep model of asthma | ||||||||||||||||||||
| 参考文献： | 1. Chris P Carron, et al. Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS). ACS Med Chem Lett. 2010 Feb 2;1(2):59-63. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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北京