品牌	货号	产品规格	价格(RMB)	库存（上海）	北京	武汉	南京	购买数量
源叶(MedMol)	S81811-5mg	99%	￥3500.00元	预计交期：2-3天	-	-	-
源叶(MedMol)	S81811-10mg	99%	￥5000.00元	预计交期：2-3天	-	-	-

产品介绍

FGH10019 is a novel sterol regulatory element-binding protein (SREBP) inhibitor with IC50 of 1 μM.

产品描述：

FGH10019 is a novel sterol regulatory element-binding protein (SREBP) inhibitor with IC50 of 1 μM.

靶点：

IC50: 1 μM (SREBP);NPC1L1; FattyAcidSynthase

体外研究：

Treatment of the CHO-K1 cells with analog FGH10019 decreases the percentage of the mature form of SREBP-2 (68 kDa) at lower concentrations than treatment with fatostatin. Densitometric analysis of the gels indicates that the IC50 of analog FGH10019 is approximately 1 μM, which is 5-10 times lower than the IC50 of fatostatin (appr 10 μM)

体内研究：

FGH10019-treated chow is fed at a dose rate calculated to provide about 0.7 mg analog FGH10019 per day, at about 23 mg/kg body weight, to 5-wk-old male ob/ob mice weighing an average of appr 30 g. After 8 wk on the analog 24-treated chow, the mice gain 8-9 % less weight than control mice

参考文献：

1. Kamisuki S, et al. Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins. J Med Chem. 2011 Jul 14;54(13):4923-7.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.677 ml	13.387 ml	26.774 ml
5 mM	0.535 ml	2.677 ml	5.355 ml
10 mM	0.268 ml	1.339 ml	2.677 ml
50 mM	0.054 ml	0.268 ml	0.535 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

FGH10019