| 产品描述： | ITD-1是有效的TGF-β抑制剂。它不抑制TGFBR1或TGFBR的激酶活性，但能够有效地抑制TGFβ2诱导的效应因子SMAD2/3磷酸化，对Activin A的影响甚微 |
| 靶点： |
TGF-β;TGF-beta/Smad |
| 体外研究： |
ITD-1, a small molecule inhibitor of TGF-β signaling, can partially induce proteasomal degradation of the TβR232,33, and blocks Smad and MAPK activation |
| 体内研究： |
ITD-1 partially inhibits TGF-β signaling and renal fibrosis in unilateral ischemia-reperfusion injury (UIRI) mice |
| 细胞实验： |
Cell lines: NRK-49F cells Concentrations: 3 μM Incubation Time: 1 h Method: NRK-49F cells are pre-incubated with KP1 (10 µg/ml, 3 μM) or ITD-1 (3 μM) for 1 h, and then treated with TGF-β1 (2 ng/ml) for 45 min. Western blot analyses the protein levels of p-Smad3 and p-p38. |
| 参考文献： |
1. Erik Willems, et al. Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells. Cell Stem Cell. 2012, 11(2):242-52. 2. Yuan Q, et al. A Klotho-derived peptide protects against kidney fibrosis by targeting TGF-β signaling. Nat Commun. 2022 Jan 21;13(1):438. |
| 溶解性： |
soluble in DMSO |
| 保存条件： |
-20℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.407 ml |
12.033 ml |
24.066 ml |
| 5 mM |
0.481 ml |
2.407 ml |
4.813 ml |
| 10 mM |
0.241 ml |
1.203 ml |
2.407 ml |
| 50 mM |
0.048 ml |
0.241 ml |
0.481 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京