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• 产品描述： DMCM hydrochloride is a nonselective full inverse agonist of benzodiazepine. DMCM shows bnding afinity at human recombinant GABAA αxβ3γ2 receptor subtypes with Kis of 10 nM, 13 nM, 7.5 nM, 2.2 nM for α1, α2, α3, and α5  receptors, respectively

• 靶点： Ki: 10 nM (GABAA α1  receptor), 13 nM (GABAA α2 receptor), 7.5 nM (GABAA α3 receptor), 2.2 nM (GABAA α5  receptor);GABAReceptor

• 体内研究：
  DMCM has potent convulsant, proconvulsant and anxiogenic properties in vivo. DMCM (20-60 mg/kg; i.p.) produces modest anxiolytic-like effects in γ2I77 mice. Animal Model: Male γ2I77 mice Dosage: 20 mg/kg and 60 mg/kg Administration: Injected i.p. Result: Produced modest anxiolytic-like effects.

• 参考文献：
  1. Chambers MS, et al. An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA alpha5 receptors with cognition enhancing properties. J Med Chem. 2004 Nov 18;47(24):5829-32. 2. Leppä E, et al. Agonistic effects of the beta-carboline DMCM revealed in GABA(A) receptor gamma 2 subunit F77I point-mutated mice. Neuropharmacology. 2005 Mar;48(4):469-78.

• 溶解性： Soluble  in  DMSO、H2O

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.851 ml	14.253 ml	28.507 ml
  5 mM	0.57 ml	2.851 ml	5.701 ml
  10 mM	0.285 ml	1.425 ml	2.851 ml
  50 mM	0.057 ml	0.285 ml	0.57 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *